ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 1B (ABCB1B) antibody

Catalog No. ABIN8119874

This Rabbit Monoclonal antibody specifically detects ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 1B in ELISA, WB, IHC, IP and IF. It exhibits reactivity toward Human.

Quick Overview for ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 1B (ABCB1B) antibody (ABIN8119874)

Target: ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 1B (ABCB1B)

Reactivity: Human

Host: Rabbit

Clonality: Monoclonal

Conjugate: Un-conjugated

Application: ELISA, Western Blotting (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP), Immunofluorescence (IF)

Clone: AB2010

Product Details

Purpose: MDR1 Rabbit mAb

Specificity: This antibody detects endogenous levels of MDR1 protein.

Purification: The antibody was purified by protein A affinity chromatography.

Immunogen: Recombinant protein (or fragment).

Isotype: IgG

Application Details

Application Notes: WB, 1:2000-1:10000 | IHC, 1:200-1:1000 | IF, 1:200-1:1000 | IP, 0. 5 μg-4 μg antibody for 200 μg-400 μg extracts of whole cells. | ELISA, Recommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: The antibody is provided in liquid form in phosphate - buffered saline with 50 % glycerol, 0.05 % BSA, and 0.05 % Proclin 300.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid freeze / thaw cycles

Storage: -20 °C

Storage Comment: Store at-20°C. Avoid freeze / thaw cycles.

Target Details

Target: ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 1B (ABCB1B)

Alternative Name: MDR1

Background:

Synonyms: ABC20, ABCB1, ATP binding cassette, sub family B, MDR/TAP, , member 1, ATP-binding cassette sub-family B member 1, CD243, CLCS, Colchicin sensitivity, Doxorubicin resistance, GP170, MDR1, MDR1_HUMAN, Multidrug resistance 1, Multidrug resistance protein 1, P glycoprotein 1, P gp, P-glycoprotein 1, PGY1

Background: The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra-and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White) . This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is an ATP-dependent drug efflux pump for xenobiotic compounds with broad substrate specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs. This protein also functions as a transporter in the blood-brain barrier. [provided by RefSeq, Jul 2008],

Gene Name: ABCB1 MDR1 PGY1

Protein Name: MDR1

Gene ID: 5243

UniProt: P08183