ATR antibody

Catalog No. ABIN8119903

The Rabbit Monoclonal anti-ATR antibody (Clone AB5294) (ABIN8119903) specifically detects ATR in ELISA, WB, IHC and IF. The antibody is reactive with Human samples.

Quick Overview for ATR antibody (ABIN8119903)

Target: ATR (ATR serine/threonine kinase (ATR))

Reactivity: Human

Host: Rabbit

Clonality: Monoclonal

Conjugate: This ATR antibody is un-conjugated

Application: ELISA, Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

Clone: AB5294

Product Details anti-ATR Antibody

Purpose: ATR Rabbit mAb

Specificity: This antibody detects endogenous levels of ATR protein.

Purification: The antibody was purified by protein A affinity chromatography.

Immunogen: Recombinant protein (or fragment).

Isotype: IgG

Application Details

Application Notes: WB, 1:1000-1:2000 | IHC-P, 1:100-1:400 | IF/ICC, 1:100-1:400 | ELISA, Recommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: The antibody is provided in liquid form in phosphate - buffered saline with 50 % glycerol, 0.05 % BSA, and 0.05 % Proclin 300.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid freeze / thaw cycles

Storage: -20 °C

Storage Comment: Store at-20°C. Avoid freeze / thaw cycles.

Target Details for ATR

Target: ATR (ATR serine/threonine kinase (ATR))

Alternative Name: ATR

Background:

Synonyms: Serine/threonine-protein kinase ATR (EC 2.7.11.1) (Ataxia telangiectasia and Rad3-related protein) (FRAP-related protein 1)

Background: The protein encoded by this gene is a serine/threonine kinase and DNA damage sensor, activating cell cycle checkpoint signaling upon DNA stress. The encoded protein can phosphorylate and activate several proteins involved in the inhibition of DNA replication and mitosis, and can promote DNA repair, recombination, and apoptosis. This protein is also important for fragile site stability and centrosome duplication. Defects in this gene are a cause of Seckel syndrome 1.

Gene Name: ATR

Protein Name: ATR

Gene ID: 545

UniProt: Q13535

Pathways: Positive Regulation of Response to DNA Damage Stimulus