BCL6 antibody (acLys379)

Catalog No. ABIN8119947

The Rabbit Polyclonal anti-BCL6 antibody is suitable to detect BCL6 in samples from Human, Mouse and Rat. It has been validated for WB and ELISA.

Quick Overview for BCL6 antibody (acLys379) (ABIN8119947)

Target: BCL6 (B-Cell CLL/lymphoma 6 (BCL6))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This BCL6 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-BCL6 Antibody

Binding Specificity: acLys379

Purpose: Bcl-6 (Acetyl Lys379) Antibody

Specificity: This antibody detects endogenous levels of Human,Mouse,Rat Bcl-6 (Acetyl Lys379)

Purification: The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.

Immunogen: Synthesized peptide derived from human Bcl-6 (Acetyl Lys379)

Isotype: IgG

Application Details

Application Notes: WB 1:1000-2000 ELISA 1:5000-20000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C/1 year

Expiry Date: 12 months

Target Details for BCL6

Target: BCL6 (B-Cell CLL/lymphoma 6 (BCL6))

Alternative Name: Bcl-6

Background:

Synonyms: B-cell lymphoma 6 protein (BCL-6, B-cell lymphoma 5 protein, BCL-5, Protein LAZ-3, Zinc finger and BTB domain-containing protein 27, Zinc finger protein 51)

Background: disease:A chromosomal aberration involving BCL6 may be a cause of a form of B-cell leukemia. Translocation t(3,11)(q27,q23) with POU2AF1/OBF1.,disease:A chromosomal aberration involving BCL6 may be a cause of lymphoma. Translocation t(3,4)(q27,p11) with ARHH/TTF.,disease:Chromosomal aberrations involving BCL6 may be a cause of B-cell non-Hodgkin lymphoma. Translocation t(3,14)(q27,q32), translocation t(3,22)(q27,q11) with immunoglobulin gene regions.,function:Transcriptional repressor which is required for germinal center formation and antibody affinity maturation. Probably plays an important role in lymphomagenesis.,induction:Down-regulated during maturation of dendritic cells by selective stimuli such as LPS, CD40L and zymosan.,PTM:Phosphorylated by MAPK1 in response to antigen receptor activation. Phosphorylation induces its degradation by ubiquitin/proteasome pathway.,similarity:Contains 1 BTB (POZ) domain.,similarity:Contains 6 C2H2-type zinc fingers.,subunit:Interacts with ZBTB7 and BCL6B (By similarity). Interacts with the catalytic domain of HDAC9.,tissue specificity:Expressed in germinal center T and B cells and in primary immature dendritic cells.,

Gene Name: BCL6 BCL5 LAZ3 ZBTB27 ZNF51

Protein Name: Bcl-6 (Acetyl Lys379)

Gene ID: 604

UniProt: P41182

Pathways: Chromatin Binding, Regulation of Leukocyte Mediated Immunity, Production of Molecular Mediator of Immune Response, Protein targeting to Nucleus