Bestrophin 1 antibody (AA 161-211)

Catalog No. ABIN8119984

The Rabbit Polyclonal anti-Bestrophin 1 antibody (ABIN8119984) specifically detects Bestrophin 1 in WB, IHC and IF. The antibody is reactive with Human, Mouse and Rat samples.

Quick Overview for Bestrophin 1 antibody (AA 161-211) (ABIN8119984)

Target: Bestrophin 1 (BEST1)

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Bestrophin 1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

Product Details anti-Bestrophin 1 Antibody

Binding Specificity: AA 161-211

Purpose: Bestrophin-1 Antibody

Specificity: The antibody detects endogenous Bestrophin-1 protein

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthetic Peptide of Bestrophin-1 AA range: 161-211

Isotype: IgG

Application Details

Application Notes: WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:40000.. IF 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C/1 year

Expiry Date: 12 months

Target Details for Bestrophin 1

Target: Bestrophin 1 (BEST1)

Alternative Name: Bestrophin-1

Background:

Synonyms: Bestrophin-1 (TU15B, Vitelliform macular dystrophy protein 2)

Background: This gene encodes a member of the bestrophin gene family. This small gene family is characterized by proteins with a highly conserved N-terminus with four to six transmembrane domains. Bestrophins may form chloride ion channels or may regulate voltage-gated L-type calcium-ion channels. Bestrophins are generally believed to form calcium-activated chloride-ion channels in epithelial cells but they have also been shown to be highly permeable to bicarbonate ion transport in retinal tissue. Mutations in this gene are responsible for juvenile-onset vitelliform macular dystrophy (VMD2), also known as Best macular dystrophy, in addition to adult-onset vitelliform macular dystrophy (AVMD) and other retinopathies. Alternative splicing results in multiple variants encoding distinct isoforms.[provided by RefSeq, Nov 2008],

Gene Name: BEST1

Protein Name: Bestrophin-1 (TU15B) (Vitelliform macular dystrophy protein 2)

Gene ID: 7439

UniProt: O76090