BTRC antibody (AA 43-93)

Catalog No. ABIN8119993

The Rabbit Polyclonal anti-BTRC antibody (ABIN8119993) specifically detects BTRC in WB. The antibody is reactive with Human and Mouse samples.

Quick Overview for BTRC antibody (AA 43-93) (ABIN8119993)

Target: BTRC (beta-Transducin Repeat Containing (BTRC))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This BTRC antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-BTRC Antibody

Binding Specificity: AA 43-93

Purpose: FBW1A Antibody

Specificity: This antibody detects endogenous levels of FBW1A at Human/Mouse

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from human FBW1A AA range: 43-93

Isotype: IgG

Application Details

Application Notes: WB 1:500-2000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C/1 year

Expiry Date: 12 months

Target Details for BTRC

Target: BTRC (beta-Transducin Repeat Containing (BTRC))

Alternative Name: FBW1A

Background:

Background: This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs.The protein encoded by this gene belongs to the Fbws class, in addition to an F-box, this protein contains multiple WD-40 repeats. The encoded protein mediates degradation of CD4 via its interaction with HIV-1 Vpu. It has also been shown to ubiquitinate phosphorylated NFKBIA (nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha), targeting it for degradation and thus activating nuclear factor kappa-B. Alternatively spliced transcript variants have been described. A related pseudogene exists in chromosome 6. [provided by RefSeq, Mar 2012],

Gene Name: BTRC BTRCP FBW1A FBXW1A

Protein Name: FBW1A

Gene ID: 8945

UniProt: Q9Y297

Pathways: Cell Division Cycle, Hedgehog Signaling