CAPN10 antibody

Catalog No. ABIN8120148

The Rabbit Polyclonal anti-CAPN10 antibody is suitable to detect CAPN10 in samples from Human, Mouse and Rat. It has been validated for WB and ELISA.

Quick Overview for CAPN10 antibody (ABIN8120148)

Target: CAPN10 (Calpain 10 (CAPN10))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CAPN10 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-CAPN10 Antibody

Purpose: Calpain 10 Antibody

Specificity: Calpain 10 Polyclonal Antibody detects endogenous levels of Calpain 10 protein.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from the N-terminal region of human Calpain 10.

Isotype: IgG

Application Details

Application Notes: WB 1:500 - 1:2000. ELISA: 1:40000. Not yet tested in other applications.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C/1 year

Expiry Date: 12 months

Target Details for CAPN10

Target: CAPN10 (Calpain 10 (CAPN10))

Alternative Name: Calpain 10

Background:

Synonyms: CAPN10, KIAA1845, Calpain-10, Calcium-activated neutral proteinase 10, CANP 10

Background: Calpains represent a ubiquitous, well-conserved family of calcium-dependent cysteine proteases. The calpain proteins are heterodimers consisting of an invariant small subunit and variable large subunits. The large catalytic subunit has four domains: domain I, the N-terminal regulatory domain that is processed upon calpain activation, domain II, the protease domain, domain III, a linker domain of unknown function, and domain IV, the calmodulin-like calcium-binding domain.This gene encodes a large subunit. It is an atypical calpain in that it lacks the calmodulin-like calcium-binding domain and instead has a divergent C-terminal domain. It is similar in organization to calpains 5 and 6. This gene is associated with type 2 or non-insulin-dependent diabetes mellitus (NIDDM), and is located within the NIDDM1 region. Multiple alternative transcript variants have been described for this gene. [provided by RefSeq,

Gene Name: CAPN10

Protein Name: Calpain-10

Gene ID: 11132

UniProt: Q9HC96

Pathways: Positive Regulation of Peptide Hormone Secretion