Caspase-8 p18 antibody (Cleaved-Ser217)

Catalog No. ABIN8120241

The Rabbit Polyclonal anti-Caspase-8 p18 antibody is suitable to detect Caspase-8 p18 in samples from Human. It has been validated for WB and ELISA.

Quick Overview for Caspase-8 p18 antibody (Cleaved-Ser217) (ABIN8120241)

Target: Caspase-8 p18 (Caspase 8 Subunit P18)

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Caspase-8 p18 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-Caspase-8 p18 Antibody

Binding Specificity: AA 170-250, Cleaved-Ser217

Purpose: Cleaved-Caspase-8 p18 (S217) Antibody

Specificity: Cleaved-Caspase-8 p18 (S217) Polyclonal Antibody detects endogenous levels of Cleaved-Caspase-8 p18 (S217) protein.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from Cleaved-Caspase-8 p18 (S217) . at AA range: 170-250

Isotype: IgG

Application Details

Application Notes: WB 1:500 - 1:2000. ELISA: 1:10000. Not yet tested in other applications.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C/1 year

Expiry Date: 12 months

Target Details for Caspase-8 p18

Target: Caspase-8 p18 (Caspase 8 Subunit P18)

Alternative Name: Caspase-8 p18

Background:

Synonyms: CASP8, MCH5, Caspase-8, CASP-8, Apoptotic cysteine protease, Apoptotic protease Mch-5, CAP4, FADD-homologous ICE/ced-3-like protease, FADD-like ICE, FLICE, ICE-like apoptotic protease 5, MORT1-associated ced-3 homolog, MACH

Background: This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a prodomain, a large protease subunit, and a small protease subunit. Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits. This protein is involved in the programmed cell death induced by Fas and various apoptotic stimuli. The N-terminal FADD-like death effector domain of this protein suggests that it may interact with Fas-interacting protein FADD. This protein was detected in the insoluble fraction of the affected brain region from Huntington disease patients but not in those from normal controls, which implicated the role in neurodegenerative diseases. Many alt

Gene Name: CASP8

Protein Name: Caspase8

Gene ID: 841

UniProt: Q14790