CMA1 antibody

Catalog No. ABIN8120578

The Rabbit Polyclonal anti-CMA1 antibody (ABIN8120578) specifically detects CMA1 in WB and ELISA. The antibody is reactive with Human, Mouse and Rat samples.

Quick Overview for CMA1 antibody (ABIN8120578)

Target: CMA1 (Chymase 1, Mast Cell (CMA1))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CMA1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-CMA1 Antibody

Purpose: Chymase Antibody

Specificity: Chymase Polyclonal Antibody detects endogenous levels of Chymase protein.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from the Internal region of human Chymase.

Isotype: IgG

Application Details

Application Notes: WB 1:500 - 1:2000. ELISA: 1:20000. Not yet tested in other applications.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C/1 year

Expiry Date: 12 months

Target Details for CMA1

Target: CMA1 (Chymase 1, Mast Cell (CMA1))

Alternative Name: Chymase

Background:

Synonyms: CMA1, CYH, CYM, Chymase, Alpha-chymase, Mast cell protease I

Background: chymase 1(CMA1) Homo sapiens This gene encodes a chymotryptic serine proteinase that belongs to the peptidase family S1. It is expressed in mast cells and is thought to function in the degradation of the extracellular matrix, the regulation of submucosal gland secretion, and the generation of vasoactive peptides. In the heart and blood vessels, this protein, rather than angiotensin converting enzyme, is largely responsible for converting angiotensin I to the vasoactive peptide angiotensin II. Alternative splicing results in multiple variants. [provided by RefSeq, Apr 2015],

Gene Name: CMA1

Protein Name: Chymase

Gene ID: 1215

UniProt: P23946

Pathways: ACE Inhibitor Pathway, Peptide Hormone Metabolism, Regulation of Systemic Arterial Blood Pressure by Hormones, Carbohydrate Homeostasis