CSTB antibody (AA 20-60)

Catalog No. ABIN8120843

This Rabbit Polyclonal antibody specifically detects CSTB in IHC, ELISA and IF. It exhibits reactivity toward Human, Rat and Mouse.

Quick Overview for CSTB antibody (AA 20-60) (ABIN8120843)

Target: CSTB (Cystatin B (Stefin B) (CSTB))

Reactivity: Human, Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CSTB antibody is un-conjugated

Application: Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF)

Product Details anti-CSTB Antibody

Binding Specificity: AA 20-60

Purpose: Cystatin B Antibody

Specificity: The antibody detects endogenous Cystatin B

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthetic peptide from human protein at AA range: 20-60

Isotype: IgG

Application Details

Application Notes: IHC 1:50-200, ELISA 1:10000-20000. IF 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C/1 year

Expiry Date: 12 months

Target Details for CSTB

Target: CSTB (Cystatin B (Stefin B) (CSTB))

Alternative Name: Cystatin B

Background:

Synonyms: Cystatin-B (CPI-B, Liver thiol proteinase inhibitor, Stefin-B)

Background: The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins and kininogens.This gene encodes a stefin that functions as an intracellular thiol protease inhibitor. The protein is able to form a dimer stabilized by noncovalent forces, inhibiting papain and cathepsins l, h and b. The protein is thought to play a role in protecting against the proteases leaking from lysosomes. Evidence indicates that mutations in this gene are responsible for the primary defects in patients with progressive myoclonic epilepsy (EPM1). One type of mutation responsible for EPM1 is the expansion in the promoter region of this gene of a CCCCGCCCCGCG rep

Gene Name: CSTB CST6 STFB

Protein Name: Cystatin-B (CPI-B) (Liver thiol proteinase inhibitor) (Stefin-B)

Gene ID: 1476

UniProt: P04080

Pathways: Response to Water Deprivation