FBXW5 antibody (AA 319-369)

Catalog No. ABIN8121353

This Rabbit Polyclonal antibody specifically detects FBXW5 in WB. It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for FBXW5 antibody (AA 319-369) (ABIN8121353)

Target: FBXW5 (F-Box and WD Repeat Domain Containing 5 (FBXW5))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This FBXW5 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-FBXW5 Antibody

Binding Specificity: AA 319-369

Purpose: FBXW5 Antibody

Specificity: This antibody detects endogenous levels of FBXW5 at Human/Mouse/Rat

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from human FBXW5 AA range: 319-369

Isotype: IgG

Application Details

Application Notes: WB 1:500-2000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C/1 year

Expiry Date: 12 months

Target Details for FBXW5

Target: FBXW5 (F-Box and WD Repeat Domain Containing 5 (FBXW5))

Alternative Name: FBXW5

Background:

Synonyms: F-box/WD repeat-containing protein 5 (F-box and WD-40 domain-containing protein 5)

Background: This gene encodes a member of the F-box protein family, members of which are characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into three classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs.The protein encoded by this gene contains WD-40 domains, in addition to an F-box motif, so it belongs to the Fbw class. Alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene, however, they were found to be nonsense-mediated mRNA decay (NMD) candidates, hence not represented. [provided by RefSeq, Jul 2008],

Gene Name: FBXW5 FBW5 PP3971

Protein Name: FBXW5

Gene ID: 54461

UniProt: Q969U6