FAM111A antibody

Catalog No. ABIN8121366

The Rabbit Monoclonal anti-FAM111A antibody is suitable to detect FAM111A in samples from Human. It has been validated for IHC, WB, IF and ICC.

Quick Overview for FAM111A antibody (ABIN8121366)

Target: FAM111A (Family with Sequence Similarity 111, Member A (FAM111A))

Reactivity: Human

Host: Rabbit

Clonality: Monoclonal

Conjugate: This FAM111A antibody is un-conjugated

Application: Immunohistochemistry (IHC), Western Blotting (WB), Immunofluorescence (IF), Immunocytochemistry (ICC)

Clone: AB2252

Product Details anti-FAM111A Antibody

Purpose: FAM111A Rabbit mAb

Specificity: This antibody detects endogenous levels of FAM111A protein.

Purification: The antibody was purified by protein A affinity chromatography.

Immunogen: Recombinant protein (or fragment).

Isotype: IgG

Application Details

Application Notes: WB, 1:1000-1:5000 | IHC, 1:100-1:300 | IF, 1:100-1:300 |

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: The antibody is provided in liquid form in phosphate - buffered saline with 50 % glycerol, 0.05 % BSA, and 0.05 % Proclin 300.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid freeze / thaw cycles

Storage: -20 °C

Storage Comment: Store at-20°C. Avoid freeze / thaw cycles.

Target Details for FAM111A

Target: FAM111A (Family with Sequence Similarity 111, Member A (FAM111A))

Alternative Name: FAM111A

Background:

Synonyms: FAM111A, KIAA1895, Serine protease FAM111A,

Background: The protein encoded by this gene is cell-cycle regulated, and has nuclear localization. The C-terminal half of the protein shares homology with trypsin-like peptidases and it contains a PCNA-interacting peptide (PIP) box, that is necessary for its co-localization with proliferating cell nuclear antigen (PCNA) . Reduced expression of this gene resulted in DNA replication defects, consistent with the demonstrated role for this gene in Simian Virus 40 (SV40) viral replication. Mutations in this gene have been associated with Kenny-Caffey syndrome (KCS) type 2 and the more severe osteocraniostenosis (OCS, also known as Gracile Bone Dysplasia) , both characterized by short stature, hypoparathyroidism, bone development abnormalities, and hypocalcemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2015],

Gene Name: FAM111A, KIAA1895

Protein Name: FAM111A

Gene ID: 63901

UniProt: Q96PZ2