FGD1 antibody (AA 508-558)

Catalog No. ABIN8121548

This Rabbit Polyclonal antibody specifically detects FGD1 in WB. It exhibits reactivity toward Human and Mouse.

Quick Overview for FGD1 antibody (AA 508-558) (ABIN8121548)

Target: FGD1 (FYVE, RhoGEF and PH Domain Containing 1 (FGD1))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This FGD1 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-FGD1 Antibody

Binding Specificity: AA 508-558

Purpose: FGD1 Antibody

Specificity: This antibody detects endogenous levels of FGD1 at Human/Mouse

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from human FGD1 AA range: 508-558

Isotype: IgG

Application Details

Application Notes: WB 1:500-2000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C/1 year

Expiry Date: 12 months

Target Details for FGD1

Target: FGD1 (FYVE, RhoGEF and PH Domain Containing 1 (FGD1))

Alternative Name: FGD1

Background:

Synonyms: FYVE, RhoGEF and PH domain-containing protein 1 (Faciogenital dysplasia 1 protein) (Rho/Rac guanine nucleotide exchange factor FGD1) (Rho/Rac GEF) (Zinc finger FYVE domain-containing protein 3)

Background: This gene encodes a protein that contains Dbl (DH) and pleckstrin (PH) homology domains and is similar to the Rho family of small GTP-binding proteins. The encoded protein specifically binds to the Rho family GTPase Cdc42Hs and can stimulate the GDP-GTP exchange of the isoprenylated form of Cdc42Hs. It also stimulates the mitogen activated protein kinase cascade leading to c-Jun kinase SAPK/JNK1 activation. Defects in this gene are the cause of faciogenital dysplasia and X-linked mental retardation, syndromatic 16.[provided by RefSeq, Mar 2011],

Gene Name: FGD1 FGDY ZFYVE3

Protein Name: FGD1

Gene ID: 2245

UniProt: P98174

Pathways: Neurotrophin Signaling Pathway