GEN1 antibody (AA 61-111)

Catalog No. ABIN8121631

The Rabbit Polyclonal anti-GEN1 antibody (ABIN8121631) specifically detects GEN1 in WB. The antibody is reactive with Human and Mouse samples.

Quick Overview for GEN1 antibody (AA 61-111) (ABIN8121631)

Target: GEN1 (Gen Endonuclease Homolog 1 (GEN1))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GEN1 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-GEN1 Antibody

Binding Specificity: AA 61-111

Purpose: GEN Antibody

Specificity: This antibody detects endogenous levels of GEN at Human/Mouse

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from human GEN AA range: 61-111

Isotype: IgG

Application Details

Application Notes: WB 1:500-2000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C/1 year

Expiry Date: 12 months

Target Details for GEN1

Target: GEN1 (Gen Endonuclease Homolog 1 (GEN1))

Alternative Name: GEN

Background:

Background: This gene encodes a member of the Rad2/xeroderma pigmentosum group G nuclease family, whose members are characterized by N-terminal and internal xeroderma pigmentosum group G nuclease domains followed by helix-hairpin-helix domains and disordered C-terminal domains.The protein encoded by this gene is involved in resolution of Holliday junctions, which are intermediate four-way structures that covalently link DNA during homologous recombination and double-strand break repair. The protein resolves Holliday junctions by creating dual incisions across the junction to produce nicked duplex products that can be ligated. In addition, this protein has been found to localize to centrosomes where it has been implicated in regulation of centrosome integrity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2016],

Gene Name: GEN1

Protein Name: GEN

Gene ID: 348654

UniProt: Q17RS7

Pathways: DNA Damage Repair