GLUL antibody (AA 400-500)

Catalog No. ABIN8121691

The Mouse Monoclonal anti-GLUL antibody (Clone AB2426) (ABIN8121691) specifically detects GLUL in WB, ELISA, IHC and IF. The antibody is reactive with Human, Mouse and Rat samples.

Quick Overview for GLUL antibody (AA 400-500) (ABIN8121691)

Target: GLUL (Glutamate-Ammonia Ligase (GLUL))

Reactivity: Human, Mouse, Rat

Host: Mouse

Clonality: Monoclonal

Conjugate: This GLUL antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Clone: AB2426

Product Details anti-GLUL Antibody

Binding Specificity: AA 400-500

Purpose: Gl Syn/Glutamine Synthetase mouse mAb

Specificity: This antibody detects endogenous levels of Gl Syn/Glutamine Synthetase protein.

Purification: The antibody was purified by protein G affinity chromatography.

Immunogen: A synthetic peptide corresponding to the amino acid region 400 - 500 of the human Beta Tubulin protein.

Isotype: IgG

Application Details

Application Notes: IHC, 1:200-1:1000 | WB, 1:500-1:2000 | IF, 1:100-1:500 | ELISA, Recommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: The antibody is provided in liquid form in phosphate - buffered saline with 50 % glycerol, 0.05 % BSA, and 0.05 % Proclin 300.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid freeze / thaw cycles

Storage: -20 °C

Storage Comment: Store at-20°C. Avoid freeze / thaw cycles.

Target Details for GLUL

Target: GLUL (Glutamate-Ammonia Ligase (GLUL))

Alternative Name: Gl Syn/Glutamine Synthetase

Background:

Synonyms: GLUL,GLNS,Glutamine synthetase,GS,Glutamate decarboxylase,Glutamate-- ammonia ligase

Background: The protein encoded by this gene belongs to the glutamine synthetase family. It catalyzes the synthesis of glutamine from glutamate and ammonia in an ATP-dependent reaction. This protein plays a role in ammonia and glutamate detoxification, acid-base homeostasis, cell signaling, and cell proliferation. Glutamine is an abundant amino acid, and is important to the biosynthesis of several amino acids, pyrimidines, and purines. Mutations in this gene are associated with congenital glutamine deficiency, and overexpression of this gene was observed in some primary liver cancer samples. There are six pseudogenes of this gene found on chromosomes 2, 5, 9, 11, and 12. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014],

Gene Name: GLUL

Protein Name: Gl Syn/Glutamine Synthetase

Gene ID: 2752

UniProt: P15104

Pathways: Positive Regulation of Peptide Hormone Secretion