HES2 antibody (AA 40-120)

Catalog No. ABIN8121875

This Rabbit Polyclonal antibody specifically detects HES2 in WB and ELISA. It exhibits reactivity toward Human, Rat and Mouse.

Quick Overview for HES2 antibody (AA 40-120) (ABIN8121875)

Target: HES2 (Hairy and Enhancer of Split 2 (HES2))

Reactivity: Human, Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This HES2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-HES2 Antibody

Binding Specificity: AA 40-120

Purpose: HES2 Antibody

Specificity: HES2 Polyclonal Antibody detects endogenous levels of protein.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from human protein . at AA range: 40-120

Isotype: IgG

Application Details

Application Notes: WB 1:500-2000 ELISA 1:5000-20000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Liquid in PBS containing 50 % glycerol, and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C/1 year

Expiry Date: 12 months

Target Details for HES2

Target: HES2 (Hairy and Enhancer of Split 2 (HES2))

Alternative Name: HES2

Background:

Background: domain:Has a particular type of basic domain (presence of a helix-interrupting proline) that binds to the N-box (CACNAG), rather than the canonical E-box (CANNTG).,domain:The C-terminal WRPW motif is a transcriptional repression domain necessary for the interaction with Groucho/TLE family members, transcriptional corepressors recruited to specific target DNA by Hairy-related proteins.,function:Transcriptional repressor of genes that require a bHLH protein for their transcription.,similarity:Contains 1 basic helix-loop-helix (bHLH) domain.,similarity:Contains 1 Orange domain.,subunit:Transcription repression requires formation of a complex with a corepressor protein of the Groucho/TLE family.,tissue specificity:Expressed in placenta, pancreatic cancer, colon cancer with RER, cervical cancer, and in head and neck tumors.,

Gene Name: HES2 BHLHB40

Protein Name: Transcription factor HES-2 (Class B basic helix-loop-helix protein 40) (bHLHb40) (Hairy and enhancer of split 2)

Gene ID: 54626

UniProt: Q9Y543