Importin 9 antibody

Catalog No. ABIN8122170

The Rabbit Polyclonal anti-Importin 9 antibody is suitable to detect Importin 9 in samples from Human and Mouse. It has been validated for WB and ELISA.

Quick Overview for Importin 9 antibody (ABIN8122170)

Target: Importin 9 (IPO9)

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Importin 9 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-Importin 9 Antibody

Purpose: IPO9 Antibody

Specificity: IPO9 Polyclonal Antibody detects endogenous levels of protein.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from part region of human protein

Isotype: IgG

Application Details

Application Notes: WB 1:500-2000 ELISA 1:5000-20000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Liquid in PBS containing 50 % glycerol, and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C/1 year

Expiry Date: 12 months

Target Details for Importin 9

Target: Importin 9 (IPO9)

Alternative Name: IPO9

Background:

Background: function:Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity). Mediates the nuclear import of H2B histone (By similarity), RPS7 and RPL18A. Prevents the cytoplasmic aggregation of RPS7 and RPL18A by shielding exposed basic domains. May also import H2A, H3, H4 histones (By similarity), RPL4 and RPL6.,similarity:Belongs to the importin beta family.,similarity:Contains 1 importin N-terminal domain.,subunit:Binds with high affinity to RPS7 and RPL18A. The binding is coupled to RanGTP cycles. May bind H2A, H3, H4 histones (By similarity), RPL4 and RPL6 with low affinity. Interacts with PPP2R1A and PPP2R1B.,

Gene Name: IPO9 IMP9 KIAA1192 RANBP9 HSPC273

Protein Name: Importin-9 (Imp9) (Ran-binding protein 9) (RanBP9)

Gene ID: 55705

UniProt: Q96P70

Pathways: Protein targeting to Nucleus