INCENP antibody (pThr59)

Catalog No. ABIN8122191

The Rabbit Polyclonal anti-INCENP antibody is suitable to detect INCENP in samples from Human, Rat and Mouse. It has been validated for WB.

Quick Overview for INCENP antibody (pThr59) (ABIN8122191)

Target: INCENP (Inner Centromere Protein Antigens 135/155kDa (INCENP))

Reactivity: Human, Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This INCENP antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-INCENP Antibody

Binding Specificity: pThr59

Purpose: INCENP (Phospho Thr59) Antibody

Specificity: This antibody detects endogenous levels of INCENP (Phospho-Thr59) at Human, Mouse,Rat

Purification: The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.

Immunogen: Synthesized peptide derived from human INCENP (Phospho-Thr59)

Isotype: IgG

Application Details

Application Notes: WB 1:500-2000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C/1 year

Expiry Date: 12 months

Target Details for INCENP

Target: INCENP (Inner Centromere Protein Antigens 135/155kDa (INCENP))

Alternative Name: INCENP

Background:

Synonyms: Inner centromere protein

Background: In mammalian cells, 2 broad groups of centromere-interacting proteins have been described: constitutively binding centromere proteins and 'passenger,' or transiently interacting, proteins (reviewed by Choo, 1997). The constitutive proteins include CENPA (centromere protein A; MIM 117139), CENPB (MIM 117140), CENPC1 (MIM 117141), and CENPD (MIM 117142). The term 'passenger proteins' encompasses a broad collection of proteins that localize to the centromere during specific stages of the cell cycle (Earnshaw and Mackay, 1994 [PubMed 8088460]). These include CENPE (MIM 117143); MCAK (MIM 604538); KID (MIM 603213); cytoplasmic dynein (e.g., MIM 600112); CliPs (e.g., MIM 179838); and CENPF/mitosin (MIM 600236). The inner centromere proteins (INCENPs) (Earnshaw and Cooke, 1991 [PubMed 1860899]), the initial members of the passenger protein group, display a broad localization alo

Gene Name: INCENP

Protein Name: INCENP (Phospho-Thr59)

Gene ID: 3619

UniProt: Q9NQS7

Pathways: Cell Division Cycle