IL-15 antibody (AA 111-160)

Catalog No. ABIN8122321

The Rabbit Polyclonal anti-IL-15 antibody (ABIN8122321) specifically detects IL-15 in IHC, ELISA and IF. The antibody is reactive with Human, Rat and Mouse samples.

Quick Overview for IL-15 antibody (AA 111-160) (ABIN8122321)

Target: IL-15 (IL15) (Interleukin 15 (IL15))

Reactivity: Human, Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This IL-15 antibody is un-conjugated

Application: Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF)

Product Details anti-IL-15 Antibody

Binding Specificity: AA 111-160

Purpose: IL-15 Antibody

Specificity: The antibody detects endogenous IL-15

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthetic peptide from human protein at AA range: 111-160

Isotype: IgG

Application Details

Application Notes: IHC 1:50-200, ELISA 1:10000-20000. IF 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C/1 year

Expiry Date: 12 months

Target Details for IL-15

Target: IL-15 (IL15) (Interleukin 15 (IL15))

Alternative Name: IL-15

Background:

Synonyms: Interleukin-15 (IL-15)

Background: The protein encoded by this gene is a cytokine that regulates T and natural killer cell activation and proliferation. This cytokine and interleukine 2 share many biological activities. They are found to bind common hematopoietin receptor subunits, and may compete for the same receptor, and thus negatively regulate each other's activity. The number of CD8+ memory cells is shown to be controlled by a balance between this cytokine and IL2. This cytokine induces the activation of JAK kinases, as well as the phosphorylation and activation of transcription activators STAT3, STAT5, and STAT6. Studies of the mouse counterpart suggested that this cytokine may increase the expression of apoptosis inhibitor BCL2L1/BCL-x(L), possibly through the transcription activation activity of STAT6, and thus prevent apoptosis. Alternatively spliced transcript variants of this gene have been reported. [provided by RefSeq, Feb

Gene Name: IL15

Protein Name: Interleukin-15 (IL-15)

Gene ID: 3600

UniProt: P40933

Pathways: JAK-STAT Signaling, Glycosaminoglycan Metabolic Process