LGMN antibody (AA 60-140)

Catalog No. ABIN8122618

The Rabbit Polyclonal anti-LGMN antibody (ABIN8122618) specifically detects LGMN in WB and ELISA. The antibody is reactive with Human, Mouse and Rat samples.

Quick Overview for LGMN antibody (AA 60-140) (ABIN8122618)

Target: LGMN (Legumain (LGMN))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This LGMN antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-LGMN Antibody

Binding Specificity: AA 60-140

Purpose: LGMN Antibody

Specificity: LGMN Polyclonal Antibody detects endogenous levels of protein.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from human protein . at AA range: 60-140

Isotype: IgG

Application Details

Application Notes: WB 1:500-2000 ELISA 1:5000-20000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Liquid in PBS containing 50 % glycerol, and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C/1 year

Expiry Date: 12 months

Target Details for LGMN

Target: LGMN (Legumain (LGMN))

Alternative Name: LGMN

Background:

Background: This gene encodes a cysteine protease that has a strict specificity for hydrolysis of asparaginyl bonds. This enzyme may be involved in the processing of bacterial peptides and endogenous proteins for MHC class II presentation in the lysosomal/endosomal systems. Enzyme activation is triggered by acidic pH and appears to be autocatalytic. Protein expression occurs after monocytes differentiate into dendritic cells. A fully mature, active enzyme is produced following lipopolysaccharide expression in mature dendritic cells. Overexpression of this gene may be associated with the majority of solid tumor types. This gene has a pseudogene on chromosome 13. Several alternatively spliced transcript variants have been described, but the biological validity of only two has been determined. These two variants encode the same isoform. [provided by RefSeq, Jul 2008],

Gene Name: LGMN PRSC1

Protein Name: Legumain (EC 3.4.22.34) (Asparaginyl endopeptidase) (Protease, cysteine 1)

Gene ID: 5641

UniProt: Q99538

Pathways: Metabolism of Steroid Hormones and Vitamin D, Activation of Innate immune Response, Toll-Like Receptors Cascades