MARCH1 antibody

Catalog No. ABIN8122860

The Rabbit Polyclonal anti-MARCH1 antibody is suitable to detect MARCH1 in samples from Human, Mouse and Rat. It has been validated for ELISA, WB, IHC and IF.

Quick Overview for MARCH1 antibody (ABIN8122860)

Target: MARCH1 (Membrane-Associated Ring Finger (C3HC4) 1, E3 Ubiquitin Protein Ligase (MARCH1))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MARCH1 antibody is un-conjugated

Application: ELISA, Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

Product Details anti-MARCH1 Antibody

Purpose: MARCH1 Antibody

Specificity: MARCH1 Polyclonal Antibody detects endogenous levels of 40603 protein.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from the Internal region of human 40603.

Isotype: IgG

Application Details

Application Notes: WB 1:500-2000 IHC 1:100 - 1:300. ELISA: 1:40000.. IF 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C/1 year

Expiry Date: 12 months

Target Details for MARCH1

Target: MARCH1 (Membrane-Associated Ring Finger (C3HC4) 1, E3 Ubiquitin Protein Ligase (MARCH1))

Alternative Name: MARCH1

Background:

Synonyms: MARCH1, RNF171, E3 ubiquitin-protein ligase MARCH1, Membrane-associated RING finger protein 1, Membrane-associated RING-CH protein I, MARCH-I, RING finger protein 171

Background: MARCH1 is a member of the MARCH family of membrane-bound E3 ubiquitin ligases (EC 6.3.2.19). MARCH proteins add ubiquitin (see MIM 191339) to target lysines in substrate proteins, thereby signaling their vesicular transport between membrane compartments. MARCH1 downregulates the surface expression of major histocompatibility complex (MHC) class II molecules (see MIM 142880) and other glycoproteins by directing them to the late endosomal/lysosomal compartment (Bartee et al., 2004 [PubMed 14722266], Thibodeau et al., 2008 [PubMed 18389477], De Gassart et al., 2008 [PubMed 18305173]).[supplied by OMIM, Mar 2010],

Gene Name: MARCH1

Protein Name: E3 ubiquitin-protein ligase MARCH1

Gene ID: 55016

UniProt: Q8TCQ1