MLKL antibody (pSer358)

Catalog No. ABIN8123028

The Rabbit Polyclonal anti-MLKL antibody is suitable to detect MLKL in samples from Human. It has been validated for IHC and IF.

Quick Overview for MLKL antibody (pSer358) (ABIN8123028)

Target: MLKL (Mixed Lineage Kinase Domain-Like (MLKL))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MLKL antibody is un-conjugated

Application: Immunohistochemistry (IHC), Immunofluorescence (IF)

Product Details anti-MLKL Antibody

Binding Specificity: pSer358

Purpose: MLKL (phospho Ser358) Antibody

Specificity: This antibody detects endogenous phospho levels of MLKL (phospho S358) at Human, Mouse, Rat

Purification: The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.

Immunogen: Synthesized peptide derived from human MLKL (phospho S358)

Isotype: IgG

Application Details

Application Notes: IHC 1:100-500,IF ICC 1:100-500

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C/1 year

Expiry Date: 12 months

Target Details for MLKL

Target: MLKL (Mixed Lineage Kinase Domain-Like (MLKL))

Alternative Name: MLKL

Background:

Synonyms: Mixed lineage kinase domain-like protein

Background: This gene belongs to the protein kinase superfamily. The encoded protein contains a protein kinase-like domain, however, is thought to be inactive because it lacks several residues required for activity. This protein plays a critical role in tumor necrosis factor (TNF)-induced necroptosis, a programmed cell death process, via interaction with receptor-interacting protein 3 (RIP3), which is a key signaling molecule in necroptosis pathway. Inhibitor studies and knockdown of this gene inhibited TNF-induced necrosis. High levels of this protein and RIP3 are associated with inflammatory bowel disease in children. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Sep 2015],

Gene Name: MLKL

Protein Name: MLKL (phospho S358)

Gene ID: 197259

UniProt: Q8NB16