NPHP3 antibody (AA 1092-1142)

Catalog No. ABIN8123265

The Rabbit Polyclonal anti-NPHP3 antibody is suitable to detect NPHP3 in samples from Human and Mouse. It has been validated for WB.

Quick Overview for NPHP3 antibody (AA 1092-1142) (ABIN8123265)

Target: NPHP3 (Nephronophthisis 3 (Adolescent) (NPHP3))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This NPHP3 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-NPHP3 Antibody

Binding Specificity: AA 1092-1142

Purpose: NPHP3 Antibody

Specificity: This antibody detects endogenous levels of NPHP3 at Human/Mouse

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from human NPHP3 AA range: 1092-1142

Isotype: IgG

Application Details

Application Notes: WB 1:500-2000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C/1 year

Expiry Date: 12 months

Target Details for NPHP3

Target: NPHP3 (Nephronophthisis 3 (Adolescent) (NPHP3))

Alternative Name: NPHP3

Background:

Background: This gene encodes a protein containing a coiled-coil (CC) domain, a tubulin-tyrosine ligase (TTL) domain, and a tetratrico peptide repeat (TPR) domain. The encoded protein interacts with nephrocystin, it is required for normal ciliary development, and it functions in renal tubular development. Mutations in this gene are associated with nephronophthisis type 3, and also with renal-hepatic-pancreatic dysplasia, and Meckel syndrome type 7. Naturally occurring read-through transcripts exist between this gene and the downstream ACAD11 (acyl-CoA dehydrogenase family, member 11) gene. [provided by RefSeq, Feb 2011],

Gene Name: NPHP3 KIAA2000

Protein Name: NPHP3

Gene ID: 27031

UniProt: Q7Z494

Pathways: cAMP Metabolic Process