NUAK1 antibody (AA 530-610)

Catalog No. ABIN8123385

The Rabbit Polyclonal anti-NUAK1 antibody is suitable to detect NUAK1 in samples from Human and Mouse. It has been validated for WB and ELISA.

Quick Overview for NUAK1 antibody (AA 530-610) (ABIN8123385)

Target: NUAK1 (NUAK Family, SNF1-Like Kinase, 1 (NUAK1))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This NUAK1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-NUAK1 Antibody

Binding Specificity: AA 530-610

Purpose: NUAK1 Antibody

Specificity: NUAK1 Polyclonal Antibody detects endogenous levels of protein.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from human protein . at AA range: 530-610

Isotype: IgG

Application Details

Application Notes: WB 1:500-2000 ELISA 1:5000-20000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Liquid in PBS containing 50 % glycerol, and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C/1 year

Expiry Date: 12 months

Target Details for NUAK1

Target: NUAK1 (NUAK Family, SNF1-Like Kinase, 1 (NUAK1))

Alternative Name: NUAK1

Background:

Background: catalytic activity:ATP + a protein = ADP + a phosphoprotein.,cofactor:Magnesium.,enzyme regulation:Activated by PKB/AKT1 during glucose starvation. Activated by phosphorylation on Thr-211 by STK11 in complex with STE20-related adapter-alpha (STRAD alpha) pseudo kinase and CAB39.,function:Involved in tolerance to glucose starvation. Phosphorylates ATM. Suppresses Fas-induced apoptosis by phosphorylation of CASP6, thus suppressing the activation of the caspase and the subsequent cleavage of CFLAR.,similarity:Belongs to the protein kinase superfamily.,similarity:Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.,similarity:Contains 1 protein kinase domain.,tissue specificity:Expressed at high levels in heart and brain, and at lower levels in skeletal muscle, kidney, ovary, placenta, lung and liver.,

Gene Name: NUAK1 ARK5 KIAA0537 OMPHK1

Protein Name: NUAK family SNF1-like kinase 1 (EC 2.7.11.1) (AMPK-related protein kinase 5) (ARK5) (Omphalocele kinase 1)

Gene ID: 9891

UniProt: O60285