Oncostatin M Receptor antibody (AA 501-550)

Catalog No. ABIN8123515

The Rabbit Polyclonal anti-Oncostatin M Receptor antibody (ABIN8123515) specifically detects Oncostatin M Receptor in WB and ELISA. The antibody is reactive with Human, Mouse and Rat samples.

Quick Overview for Oncostatin M Receptor antibody (AA 501-550) (ABIN8123515)

Target: Oncostatin M Receptor (OSMR)

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Oncostatin M Receptor antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-Oncostatin M Receptor Antibody

Binding Specificity: AA 501-550

Purpose: IL-31RB Antibody

Specificity: This antibody detects endogenous levels of Human IL-31RB

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from human IL-31RB AA range: 501-550

Isotype: IgG

Application Details

Application Notes: WB 1:1000-2000 ELISA 1:5000-20000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C/1 year

Expiry Date: 12 months

Target Details for Oncostatin M Receptor

Target: Oncostatin M Receptor (OSMR)

Alternative Name: IL-31RB

Background:

Synonyms: Oncostatin-M-specific receptor subunit beta (Interleukin-31 receptor subunit beta, IL-31 receptor subunit beta, IL-31R subunit beta, IL-31R-beta, IL-31RB)

Background: disease:Defects in OSMR are the cause of amyloidosis type 9 (AMYL9) [MIM:105250], also known as primary cutaneous amyloidosis (PCA), primary localized cutaneous amyloidosis (PLCA), familial lichen amyloidosis or familial cutaneous lichen amyloidosis. AMYL9 is a hereditary primary amyloidosis characterized by localized cutaneous amyloid deposition. This condition usually presents with itching (especially on the lower legs) and visible changes of skin hyperpigmentation and thickening (lichenification) that may be exacerbated by chronic scratching and rubbing. The amyloid deposits probably reflect a combination of degenerate keratin filaments, serum amyloid P component, and deposition of immunoglobulins.,domain:The box 1 motif is required for JAK interaction and/or activation.,domain:The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.,function:Associates with IL31RA to form the IL31 receptor. Binds IL31 to activate STAT3 and possibly STAT1 and STAT5. Capable of transducing OSM-specific signaling events.,induction:Activated by oncostatin-M. Up-regulated by IFNG and lipopolysaccharide.,similarity:Belongs to the type I cytokine receptor family. Type 2 subfamily.,similarity:Contains 4 fibronectin type-III domains.,subunit:Heterodimer composed of OSMR and IL6ST (type II OSM receptor). Heterodimer with IL31RA to form the IL31 receptor.,tissue specificity:Expressed at relatively high levels in all neural cells as well as fibroblast, epithelial and a variety of tumor cell lines.,

Gene Name: OSMR OSMRB

Protein Name: IL-31RB

Gene ID: 9180

UniProt: Q99650

Pathways: JAK-STAT Signaling, Growth Factor Binding