P-Cadherin antibody

Catalog No. ABIN8123547

The Mouse Monoclonal anti-P-Cadherin antibody is suitable to detect P-Cadherin in samples from Human. It has been validated for WB, IHC, ELISA and IF.

Quick Overview for P-Cadherin antibody (ABIN8123547)

Target: P-Cadherin (CDH3)

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This P-Cadherin antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF)

Clone: AB1019

Product Details anti-P-Cadherin Antibody

Purpose: P-cadherin mouse mAb

Specificity: This antibody detects endogenous levels of P-cadherin protein.

Purification: The antibody was purified by protein G affinity chromatography.

Immunogen: A synthetic peptide corresponding to the amino acid region 450-550 of the human P-cadherin protein.

Isotype: IgG

Application Details

Application Notes: WB, 1:500-1:2000 | IHC-P, 1:50-1:200 | IF, 1:100-400 | ELISA, Recommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: The antibody is provided in liquid form in phosphate - buffered saline with 50 % glycerol, 0.05 % BSA, and 0.05 % Proclin 300.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid freeze / thaw cycles

Storage: -20 °C

Storage Comment: Store at-20°C. Avoid freeze / thaw cycles.

Target Details for P-Cadherin

Target: P-Cadherin (CDH3)

Alternative Name: P-cadherin

Background:

Synonyms: Cadherin-3 (Placental cadherin) (P-cadherin)

Background: cadherin 3(CDH3) Homo sapiens This gene encodes a classical cadherin of the cadherin superfamily. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature glycoprotein. This calcium-dependent cell-cell adhesion protein is comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. This gene is located in a gene cluster in a region on the long arm of chromosome 16 that is involved in loss of heterozygosity events in breast and prostate cancer. In addition, aberrant expression of this protein is observed in cervical adenocarcinomas. Mutations in this gene are associated with hypotrichosis with juvenile macular dystrophy and ectodermal dysplasia, ectrodactyly, and macular dystrophy syndrome (EEMS). [provided by RefSeq, Nov 2015],

Gene Name: CADH3

Protein Name: P-cadherin

Gene ID: 1001

UniProt: P22223