PEN2 antibody (AA 51-101)

Catalog No. ABIN8123930

This Rabbit Polyclonal antibody specifically detects PEN2 in IF and IHC. It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for PEN2 antibody (AA 51-101) (ABIN8123930)

Target: PEN2 (PSENEN) (Presenilin Enhancer 2 Homolog (PSENEN))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PEN2 antibody is un-conjugated

Application: Immunofluorescence (IF), Immunohistochemistry (IHC)

Product Details anti-PEN2 Antibody

Binding Specificity: AA 51-101

Purpose: PEN2 Antibody

Specificity: This antibody detects endogenous levels of PEN2 at Human/Mouse/Rat

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from human PEN2 AA range: 51-101

Isotype: IgG

Application Details

Application Notes: IHC 1:50-200. IF 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C/1 year

Expiry Date: 12 months

Target Details for PEN2

Target: PEN2 (PSENEN) (Presenilin Enhancer 2 Homolog (PSENEN))

Alternative Name: PEN2

Background:

Background: Presenilins, which are components of the gamma-secretase protein complex, are required for intramembranous processing of some type I transmembrane proteins, such as the Notch proteins and the beta-amyloid precursor protein. Signaling by Notch receptors mediates a wide range of developmental cell fates. Processing of the beta-amyloid precursor protein generates neurotoxic amyloid beta peptides, the major component of senile plaques associated with Alzheimer's disease.This gene encodes a protein that is required for Notch pathway signaling, and for the activity and accumulation of gamma-secretase. Mutations resulting in haploinsufficiency for this gene cause familial acne inversa-2 (ACNINV2). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013],

Gene Name: PSENEN PEN2 MDS033

Protein Name: PEN2

Gene ID: 55851

UniProt: Q9NZ42

Pathways: Notch Signaling, Neurotrophin Signaling Pathway