PTGIS antibody

Catalog No. ABIN8124006

The Rabbit Polyclonal anti-PTGIS antibody is suitable to detect PTGIS in samples from Human, Mouse and Rat. It has been validated for WB, ELISA and IHC.

Quick Overview for PTGIS antibody (ABIN8124006)

Target: PTGIS (Prostaglandin I2 (Prostacyclin) Synthase (PTGIS))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PTGIS antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Product Details anti-PTGIS Antibody

Purpose: PGI2 synthase Antibody

Specificity: PGI2 synthase Polyclonal Antibody detects endogenous levels of PGI2 synthase protein.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from the C-terminal region of human PGI2 synthase.

Isotype: IgG

Application Details

Application Notes: WB 1:500-2000,IHC 1:50-300, ELISA 2000-20000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C/1 year

Expiry Date: 12 months

Target Details for PTGIS

Target: PTGIS (Prostaglandin I2 (Prostacyclin) Synthase (PTGIS))

Alternative Name: PGI2 synthase

Background:

Synonyms: PTGIS, CYP8, CYP8A1, Prostacyclin synthase, Prostaglandin I2 synthase

Background: This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. However, this protein is considered a member of the cytochrome P450 superfamily on the basis of sequence similarity rather than functional similarity. This endoplasmic reticulum membrane protein catalyzes the conversion of prostglandin H2 to prostacyclin (prostaglandin I2), a potent vasodilator and inhibitor of platelet aggregation. An imbalance of prostacyclin and its physiological antagonist thromboxane A2 contribute to the development of myocardial infarction, stroke, and atherosclerosis. [provided by RefSeq, Jul 2008],

Gene Name: PTGIS

Protein Name: Prostacyclin synthase

Gene ID: 5740

UniProt: Q16647