RPS6KA2 antibody (pThr353)

Catalog No. ABIN8124415

The Rabbit Polyclonal anti-RPS6KA2 antibody (ABIN8124415) specifically detects RPS6KA2 in WB and ELISA. The antibody is reactive with Human and Mouse samples.

Quick Overview for RPS6KA2 antibody (pThr353) (ABIN8124415)

Target: RPS6KA2 (Ribosomal Protein S6 Kinase, 90kDa, Polypeptide 2 (RPS6KA2))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This RPS6KA2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-RPS6KA2 Antibody

Binding Specificity: pThr353

Purpose: RSK3 (Phospho Thr353) Antibody

Specificity: This antibody detects endogenous levels of Human,Mouse RSK3 (Phospho Thr353)

Purification: The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.

Immunogen: Synthesized peptide derived from human RSK3 (Phospho Thr353)

Isotype: IgG

Application Details

Application Notes: WB 1:1000-2000 ELISA 1:5000-20000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C/1 year

Expiry Date: 12 months

Target Details for RPS6KA2

Target: RPS6KA2 (Ribosomal Protein S6 Kinase, 90kDa, Polypeptide 2 (RPS6KA2))

Alternative Name: RSK3

Background:

Synonyms: Ribosomal protein S6 kinase alpha-2 (S6K-alpha-2, EC 2.7.11.1, 90 kDa ribosomal protein S6 kinase 2, p90-RSK 2, p90RSK2, MAP kinase-activated protein kinase 1c, MAPK-activated protein kinase 1c, MAPKAP kinase 1c, MAPKAPK-1c, Ribosomal S6 kinase 3, RSK-3, pp90RSK3)

Background: catalytic activity:ATP + a protein = ADP + a phosphoprotein.,cofactor:Magnesium.,enzyme regulation:Activated by multiple phosphorylations on threonine and serine residues.,function:Serine/threonine kinase that may play a role in mediating the growth-factor and stress induced activation of the transcription factor CREB.,PTM:Autophosphorylated on Ser-377, as part of the activation process.,similarity:Belongs to the protein kinase superfamily.,similarity:Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.,similarity:Contains 1 AGC-kinase C-terminal domain.,similarity:Contains 2 protein kinase domains.,subunit:Forms a complex with either ERK1 or ERK2 in quiescent cells. Transiently dissociates following mitogenic stimulation.,tissue specificity:Expressed in many tissues. Highest expression in lung and skeletal muscle.,

Gene Name: RPS6KA2 MAPKAPK1C RSK3

Protein Name: RSK3 (Phospho Thr353)

Gene ID: 6196

UniProt: Q15349

Pathways: MAPK Signaling, Neurotrophin Signaling Pathway, Regulation of Systemic Arterial Blood Pressure by Hormones, Activation of Innate immune Response, Toll-Like Receptors Cascades