SIGLEC-5,SIGLEC-14 (AA 91-140) antibody

Catalog No. ABIN8124677

This Rabbit Polyclonal antibody specifically detects SIGLEC-5,SIGLEC-14 in ELISA, IF, WB and IHC. It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for SIGLEC-5,SIGLEC-14 (AA 91-140) antibody (ABIN8124677)

Target: SIGLEC-5,SIGLEC-14

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: Un-conjugated

Application: ELISA, Immunofluorescence (IF), Western Blotting (WB), Immunohistochemistry (IHC)

Product Details

Binding Specificity: AA 91-140

Purpose: Siglec-5/14 Antibody

Specificity: Siglec-5/14 Polyclonal Antibody detects endogenous levels of Siglec-5/14 protein.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from Sialic acid-binding Ig-like lectin 5/Sialic acid-binding Ig-like lectin 14 at AA range: 91-140

Isotype: IgG

Application Details

Application Notes: WB 1:500 - 1:2000. IHC: 1:100-300 ELISA: 1:20000.. IF 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C/1 year

Expiry Date: 12 months

Target Details

Target: SIGLEC-5,SIGLEC-14

Alternative Name: Siglec-5/14

Background:

Synonyms: SIGLEC5, CD33L2, OBBP2, Sialic acid-binding Ig-like lectin 5, Siglec-5, CD33 antigen-like 2, Obesity-binding protein 2, OB-BP2, OB-binding protein 2, CD170, SIGLEC14, Sialic acid-binding Ig-like lectin 14, Siglec-14

Background: This gene encodes a member of the sialic acid-binding immunoglobulin-like lectin (Siglec) family. These cell surface lectins are characterized by structural motifs in the immunoglobulin (Ig)-like domains and sialic acid recognition sites in the first Ig V set domain. The encoded protein is a member of the CD33-related subset of Siglecs and inhibits the activation of several cell types including monocytes, macrophages and neutrophils. Binding of group B Streptococcus (GBS) to the encoded protein plays a role in GBS immune evasion. [provided by RefSeq, Feb 2012],

Gene Name: SIGLEC5/SIGLEC14

Protein Name: Sialic acid-binding Ig-like lectin 5/Sialic acid-binding Ig-like lectin 14

Gene ID: 8778

UniProt: O15389