TLR3 antibody (pTyr759)

Catalog No. ABIN8125237

The Rabbit Polyclonal anti-TLR3 antibody (ABIN8125237) specifically detects TLR3 in WB. The antibody is reactive with Human, Mouse and Rat samples.

Quick Overview for TLR3 antibody (pTyr759) (ABIN8125237)

Target: TLR3 (Toll-Like Receptor 3 (TLR3))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TLR3 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-TLR3 Antibody

Binding Specificity: pTyr759

Purpose: TLR3 (Phospho Tyr759) Antibody

Specificity: This antibody detects endogenous levels of TLR3 (Phospho-Tyr759) at Human, Mouse,Rat

Purification: The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.

Immunogen: Synthesized peptide derived from human TLR3 (Phospho-Tyr759)

Isotype: IgG

Application Details

Application Notes: WB 1:500-2000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C/1 year

Expiry Date: 12 months

Target Details for TLR3

Target: TLR3 (Toll-Like Receptor 3 (TLR3))

Alternative Name: TLR3

Background:

Synonyms: Toll-like receptor 3 (CD antigen CD283)

Background: The protein encoded byThis gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This receptor is most abundantly expressed in placenta and pancreas, and is restricted to the dendritic subpopulation of the leukocytes. It recognizes dsRNA associated with viral infection, and induces the activation of NF-kappaB and the production of type I interferons. It may thus play a role in host defense against viruses. Use of alternative polyadenylation sites to generate

Gene Name: TLR3

Protein Name: TLR3 (Phospho-Tyr759)

Gene ID: 7098

UniProt: O15455

Pathways: TLR Signaling, Activation of Innate immune Response, Hepatitis C, Toll-Like Receptors Cascades