Topoisomerase II alpha antibody (AA 1400-1531)

Catalog No. ABIN8125245

The Rabbit Monoclonal anti-Topoisomerase II alpha antibody is suitable to detect Topoisomerase II alpha in samples from Human and Mouse. It has been validated for IHC.

Quick Overview for Topoisomerase II alpha antibody (AA 1400-1531) (ABIN8125245)

Target: Topoisomerase II alpha (TOP2A) (Topoisomerase (DNA) II alpha 170kDa (TOP2A))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Monoclonal

Conjugate: This Topoisomerase II alpha antibody is un-conjugated

Application: Immunohistochemistry (IHC)

Clone: AB1722

Product Details anti-Topoisomerase II alpha Antibody

Binding Specificity: AA 1400-1531

Purpose: Topoisomerase IIα Rabbit mAb (Ready to Use)

Specificity: The antibody can specifically recognize human Topoisomerase IIα protein.

Purification: The antibody was purified by protein A affinity chromatography.

Immunogen: A synthetic peptide corresponding to the amino acid region 1400 - 1531 of the human Topoisomerase IIalpha protein.

Isotype: IgG

Application Details

Application Notes: It has been optimized for direct use, requiring no further dilution.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: The ready - to - use antibody is provided in liquid form in phosphate buffer saline containing stabilizing protein and 0. 05 % Proclin 300.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid freeze

Storage: 4 °C

Storage Comment: Store at 4°C. Avoid freeze.

Target Details for Topoisomerase II alpha

Target: Topoisomerase II alpha (TOP2A) (Topoisomerase (DNA) II alpha 170kDa (TOP2A))

Alternative Name: Topoisomerase IIalpha

Background:

Synonyms: alpha isozyme,ATP hydrolyzing DNA topoisomerase II alfa,DNA gyrase,DNA topoisomerase (ATP hydrolyzing) ,DNA topoisomerase 2 alpha,DNA topoisomerase 2-alpha,DNA topoisomerase II 170 kD,DNA topoisomerase II alpha isozyme,DNA topoisomerase II,DNA Topoisomerase2,TOP 2A,TOP2,TOP2A,TOP2A_HUMAN,Topoisomerase DNA II alpha 170 kDa,TP2A

Background: Topoisomerase IIα (Topo IIα) is a nuclear protein with a molecular weight of 170 kDa. It belongs to the topoisomerase family and is expressed in proliferating cells. The main function is to maintain the spatial conformation of DNA and ensure its function. It is mainly used for the study of drug resistance.

Gene Name: TOP2A

Protein Name: Topoisomerase IIα

Gene ID: 7153

UniProt: P11388

Pathways: Cell Division Cycle, Mitotic G1-G1/S Phases