TYK2 antibody (pTyr1054)

Catalog No. ABIN8125502

This Rabbit Polyclonal antibody specifically detects TYK2 in WB. It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for TYK2 antibody (pTyr1054) (ABIN8125502)

Target: TYK2 (Tyrosine Kinase 2 (TYK2))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TYK2 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-TYK2 Antibody

Binding Specificity: pTyr1054

Purpose: Tyk2 (Phospho Tyr1054/1055) Antibody

Specificity: This antibody detects endogenous levels of Human Tyk2 (phospho-Tyr1054 or 1055)

Purification: The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.

Immunogen: Synthesized phosho peptide around human Tyk2 (Tyr1054 and 1055)

Isotype: IgG

Application Details

Application Notes: WB 1:1000-2000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C/1 year

Expiry Date: 12 months

Target Details for TYK2

Target: TYK2 (Tyrosine Kinase 2 (TYK2))

Alternative Name: Tyk2

Background:

Synonyms: Non-receptor tyrosine-protein kinase TYK2 (EC 2.7.10.2)

Background: tyrosine kinase 2(TYK2) Homo sapiens This gene encodes a member of the tyrosine kinase and, more specifically, the Janus kinases (JAKs) protein families. This protein associates with the cytoplasmic domain of type I and type II cytokine receptors and promulgate cytokine signals by phosphorylating receptor subunits. It is also component of both the type I and type III interferon signaling pathways. As such, it may play a role in anti-viral immunity. A mutation in this gene has been associated with hyperimmunoglobulin E syndrome (HIES) - a primary immunodeficiency characterized by elevated serum immunoglobulin E. [provided by RefSeq, Jul 2008],

Gene Name: TYK2

Protein Name: Tyk2 (Tyr1054/1055)

Gene ID: 7297

UniProt: P29597

Pathways: JAK-STAT Signaling, Hepatitis C