Zona Pellucida Glycoprotein 3 antibody (AA 210-260)

Catalog No. ABIN8125837

The Rabbit Polyclonal anti-Zona Pellucida Glycoprotein 3 antibody (ABIN8125837) specifically detects Zona Pellucida Glycoprotein 3 in WB. The antibody is reactive with Human, Rat and Mouse samples.

Quick Overview for Zona Pellucida Glycoprotein 3 antibody (AA 210-260) (ABIN8125837)

Target: Zona Pellucida Glycoprotein 3 (ZP3)

Reactivity: Human, Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Zona Pellucida Glycoprotein 3 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-Zona Pellucida Glycoprotein 3 Antibody

Binding Specificity: AA 210-260

Purpose: ZP3 Antibody

Specificity: This antibody detects endogenous levels of ZP3 at Human/Mouse/Rat

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from human ZP3 AA range: 210-260

Isotype: IgG

Application Details

Application Notes: WB 1:500-2000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C/1 year

Expiry Date: 12 months

Target Details for Zona Pellucida Glycoprotein 3

Target: Zona Pellucida Glycoprotein 3 (ZP3)

Alternative Name: ZP3

Background:

Background: The zona pellucida is an extracellular matrix that surrounds the oocyte and early embryo. It is composed primarily of three or four glycoproteins with various functions during fertilization and preimplantation development.The protein encoded by this gene is a structural component of the zona pellucida and functions in primary binding and induction of the sperm acrosome reaction. The nascent protein contains a N-terminal signal peptide sequence, a conserved ZP domain, a C-terminal consensus furin cleavage site, and a transmembrane domain. It is hypothesized that furin cleavage results in release of the mature protein from the plasma membrane for subsequent incorporation into the zona pellucida matrix. However, the requirement for furin cleavage in this process remains controversial based on mouse studies. A variation in the last exon of this gene has previously served as the basis for an additional ZP3 locus, however, sequence and literature review reveals that there is only one full-length ZP3 locus in the human genome. Another locus encoding a bipartite transcript designated POMZP3 contains a duplication of the last four exons of ZP3, including the above described variation, and maps closely to this gene. [provided by RefSeq, Jul 2008],

Gene Name: ZP3 ZP3A ZP3B ZPC

Protein Name: ZP3

Gene ID: 7784

UniProt: P21754

Pathways: Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process