Nicastrin antibody (PE)

Catalog No. ABIN761811

The PE-conjugated Rabbit Polyclonal anti-Nicastrin antibody (ABIN761811) specifically detects Nicastrin in WB. The antibody is reactive with Human, Mouse, Rat, Chicken, Cow and Pig samples.

Quick Overview for Nicastrin antibody (PE) (ABIN761811)

Target: Nicastrin (NCSTN)

Reactivity: Human, Mouse, Rat, Chicken, Cow, Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Nicastrin antibody is conjugated to PE

Application: Western Blotting (WB)

Product Details anti-Nicastrin Antibody (PE)

Cross-Reactivity: Mouse

Predicted Reactivity: Human,Rat,Cow,Pig,Horse,Chicken

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human Nicastrin

Isotype: IgG

Application Details

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for Nicastrin

Target: Nicastrin (NCSTN)

Alternative Name: Nicastrin

Background:

Synonyms: ATAG1874, Nicastrin, NCSTN, KIAA0253, UNQ1874/PRO4317

Background: Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta-amyloid precursor protein). It probably represents a stabilizing cofactor required for the assembly of the gamma-secretase complex.

Molecular Weight: 85kDa

Gene ID: 23385

UniProt: Q92542

Pathways: Notch Signaling, Neurotrophin Signaling Pathway