RIN1 antibody (AA 201-300)

Catalog No. ABIN762341

The Rabbit Polyclonal anti-RIN1 antibody is suitable to detect RIN1 in samples from Rat. It has been validated for ELISA, IF (cc), IF (p), ICC, IHC (fro) and IHC (p).

Quick Overview for RIN1 antibody (AA 201-300) (ABIN762341)

Target: RIN1 (Ras and Rab Interactor 1 (RIN1))

Reactivity: Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This RIN1 antibody is un-conjugated

Application: ELISA, Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunocytochemistry (ICC), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-RIN1 Antibody

Binding Specificity: AA 201-300

Cross-Reactivity: Rat

Predicted Reactivity: Human,Mouse,Cow,Pig

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human RIN1

Isotype: IgG

Application Details

Application Notes: ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200
ICC 1:100-500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

Target Details for RIN1

Target: RIN1 (Ras and Rab Interactor 1 (RIN1))

Alternative Name: Rin1

Background:

Synonyms: Ras and Rab interactor 1, ras inhibitor 1, ras inhibitor, RIN1_HUMAN, Ras inhibitor JC99, ras inhibitor RIN1, Ras interaction/interference protein 1, RIN 1.

Background: RIN1 is a Ras effector protein which can affect Ras signaling in a variety of ways. It enhances signaling from ABL1 and ABL2 whcih are involved in regulation of cytoskeletal remodeling. It may function as a guanine nucleotide exchange factor in activation of Rab5a. Rin1 also competes with RAF1 for binding of the activated form of Ras. It may play a role inhibiting the modulation of neuronal plasticity in formation of aversive memory, and has been implicated as a tumor supressor gene in breast cancer.

Gene ID: 9610