Retinoblastoma Binding Protein 8 antibody (AA 621-720)

Catalog No. ABIN762956

The Rabbit Polyclonal anti-Retinoblastoma Binding Protein 8 antibody has been validated for ELISA, WB, IHC (p), IHC (fro), IF (cc) and IF (p). It is suitable to detect Retinoblastoma Binding Protein 8 in samples from Human.

Quick Overview for Retinoblastoma Binding Protein 8 antibody (AA 621-720) (ABIN762956)

Target: Retinoblastoma Binding Protein 8 (RBBP8)

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Retinoblastoma Binding Protein 8 antibody is un-conjugated

Application: ELISA, Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Product Details anti-Retinoblastoma Binding Protein 8 Antibody

Binding Specificity: AA 621-720

Predicted Reactivity: Human,Mouse,Rat,Pig,Chicken

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human CtIP/RBBP8

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

Target Details for Retinoblastoma Binding Protein 8

Target: Retinoblastoma Binding Protein 8 (RBBP8)

Alternative Name: Ctip

Background:

Synonyms: COM1_HUMAN antibody CtBP interacting protein antibody CtBP-interacting protein antibody CtIP antibody DNA endonuclease RBBP8, RBBBP8, RBBP-8, RBBP8, Retinoblastoma-binding protein 8, Retinoblastoma-interacting protein and myosin-like, RIM, SAE2, Sporulation in the absence of SPO11 protein 2 homolog.

Background: The protein encoded by this gene is a ubiquitously expressed nuclear protein. It is found among several proteins that bind directly to retinoblastoma protein, which regulates cell proliferation. This protein complexes with transcriptional co-repressor CTBP. It is also associated with BRCA1 and is thought to modulate the functions of BRCA1 in transcriptional regulation, DNA repair, and/or cell cycle checkpoint control. It is suggested that this gene may itself be a tumor suppressor acting in the same pathway as BRCA1. Three transcript variants encoding two different isoforms have been found for this gene. More transcript variants exist, but their full-length natures have not been determined.

Gene ID: 5932

Pathways: Cell Division Cycle, DNA Damage Repair