BMI1 antibody

Catalog No. ABIN781174

The Mouse Monoclonal anti-BMI1 antibody (ABIN781174) specifically detects BMI1 in WB and ELISA. The antibody is reactive with Human samples.

Quick Overview for BMI1 antibody (ABIN781174)

Target: BMI1 (BMI1 Polycomb Ring Finger Oncogene (BMI1))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This BMI1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-BMI1 Antibody

Specificity: Nucleus

Purification: Protein G-Sepharose affinity purified

Immunogen: Synthetic peptide from the N-terminal region of human Bmi1, conjugated to KLH.

Isotype: IgG

Application Details

Application Notes: Recommended dilutions. ELISA: 1/5000 - 1/20000. WB: 1/100-1/2000.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 50µg/50µl

Buffer: 0.02% Sodium Azide and 50% glycerol, 1% BSA, PBS, pH7.4.

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Target Details for BMI1

Target: BMI1 (BMI1 Polycomb Ring Finger Oncogene (BMI1))

Alternative Name: Bmi1

Background: The Bmi1 oncogene induces telomerase activity and immortalizes human mammary epithelial cells. Bmi1 extends the replicative life span of human fibroblasts by suppressing the p16-dependent senescence pathway. Bmi1 plays a central role in the inheritance of stemness, and its forced expression promotes HSC self-renewal. These findings highlight the importance of epigenetic regulation in HSC self-renewal and identify PcG genes as potential targets for therapeutic HSC manipulation.

Molecular Weight: 37kDa

NCBI Accession: NM_005180

Pathways: Cell Division Cycle, Autophagy