GLS2 antibody (Center)
-
- Target See all GLS2 Antibodies
- GLS2 (Glutaminase 2 (Liver, Mitochondrial) (GLS2))
-
Binding Specificity
- Center
-
Reactivity
- Human, Mouse, Rat
-
Host
- Rabbit
-
Clonality
- Polyclonal
-
Conjugate
- This GLS2 antibody is un-conjugated
-
Application
- Western Blotting (WB), Enzyme Immunoassay (EIA)
- Specificity
- This antibody detects Glutaminase liver isoform at Center. GLS2 antibody is predicted to not cross-react with other catenin family members. Multiple isoforms of GLS2 are known to exist.
- Cross-Reactivity (Details)
- Species reactivity (tested):Human, mouse, rat
- Purification
- Affinity chromatography purified via peptide column
- Immunogen
- 18 amino acid peptide near the center terminus of human GLS2
- Top Product
- Discover our top product GLS2 Primary Antibody
-
anti-Glutaminase 2 (Liver, Mitochondrial) (GLS2) (AA 154-479) antibody
GLS2 Reactivity: Mouse WB, IHC, ICC, IP Host: Rabbit Polyclonal unconjugated
anti-Glutaminase 2 (Liver, Mitochondrial) (GLS2) (Middle Region) antibodyGLS2 Reactivity: Human, Mouse, Rat, Dog, Horse, Pig, Zebrafish (Danio rerio), Cow, Guinea Pig, Rabbit WB, IHC Host: Rabbit Polyclonal unconjugated
anti-Glutaminase 2 (Liver, Mitochondrial) (GLS2) (AA 498-524) antibodyGLS2 Reactivity: Human, Mouse WB, IHC (p) Host: Rabbit Polyclonal RB20072 unconjugated
anti-Glutaminase 2 (Liver, Mitochondrial) (GLS2) antibodyGLS2 Reactivity: Human, Mouse WB, IHC (p) Host: Mouse Monoclonal 1758CT879-217-60 unconjugated
anti-Glutaminase 2 (Liver, Mitochondrial) (GLS2) (AA 241-290) antibodyGLS2 Reactivity: Human, Mouse, Rat, Dog, Horse, Pig, Zebrafish (Danio rerio), Bat WB, IHC, IHC (p) Host: Rabbit Polyclonal unconjugated
anti-Glutaminase 2 (Liver, Mitochondrial) (GLS2) (AA 15-602) antibodyGLS2 Reactivity: Human ELISA, IF Host: Rabbit Polyclonal unconjugated
anti-Glutaminase 2 (Liver, Mitochondrial) (GLS2) (AA 41-140) antibodyGLS2 Reactivity: Rat ELISA, IF (cc), IF (p), IHC (p), ICC, IHC (fro) Host: Rabbit Polyclonal unconjugated
anti-Glutaminase 2 (Liver, Mitochondrial) (GLS2) (AA 150-178) antibodyGLS2 Reactivity: Human WB Host: Mouse Monoclonal 585CT26-3-1 unconjugated
anti-Glutaminase 2 (Liver, Mitochondrial) (GLS2) (C-Term) antibodyGLS2 Reactivity: Human, Mouse, Rat WB, ELISA Host: Rabbit Polyclonal unconjugated
-
- Application Notes
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
-
- Buffer
- PBS containing 0.02 % sodium azide
- Preservative
- Sodium azide
- Precaution of Use
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handling Advice
- Avoid repeated freezing and thawing.
- Storage
- 4 °C/-20 °C
- Storage Comment
- Store at 2 - 8 °C for up to three months or (in aliquots) at -20 °C for longer.
-
- Target
- GLS2 (Glutaminase 2 (Liver, Mitochondrial) (GLS2))
- Abstract
- GLS2 Products
- Background
- Phosphate-activated glutaminase, also known as Glutaminase 2 (GLS2), was initially isolated from rat liver, although it has been shown to be expressed in other tissues. Like the functionally similar, larger kidney glutaminase, GLS2 catalyzes the hydrolysis of glutamine to stoichiometric amounts of glutamate and ammonia. Expression of GLS2 is increased by p53 under both stressed and nonstressed conditions, resulting in increased levels of glutamate and ?-ketoglutarate, which in turn results in enhanced mitochondrial respiration and ATP generation. GLS2 also regulates antioxidant defense function in cells by increasing reduced glutathione levels and decreasing ROS-levels, suggesting that GLS2 acts as a mediator of p53's role in antioxidant defense in addition to its role in energy metabolism.Synonyms: GA, GLS2, L-glutaminase, L-glutamine amidohydrolase
- Gene ID
- 27165
- NCBI Accession
- NP_037399
- UniProt
- Q9UI32
- Pathways
- Dicarboxylic Acid Transport, Warburg Effect
-
