SIRT3 antibody (Center)

Catalog No. ABIN783622

This Chicken Polyclonal antibody specifically detects SIRT3 in WB and EIA. It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for SIRT3 antibody (Center) (ABIN783622)

Target: SIRT3 (Sirtuin 3 (SIRT3))

Reactivity: Human, Mouse, Rat

Host: Chicken

Clonality: Polyclonal

Conjugate: This SIRT3 antibody is un-conjugated

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Product Details anti-SIRT3 Antibody

Binding Specificity: Center

Cross-Reactivity (Details): Species reactivity (tested):Human, mouse, rat

Purification: Affinity chromatography purified via peptide column

Immunogen: 17 amino acid peptide near the center of human SIRT3

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: PBS containing 0.02 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: -20 °C

Storage Comment: Store the antibody (in aliquots) at -20 °C.

Target Details for SIRT3

Target: SIRT3 (Sirtuin 3 (SIRT3))

Alternative Name: SIRT3

Background: The Silent Information Regulator (SIR2) family of genes are highly conserved from prokaryotes to eukaryotes and have important functions in the regulation of metabolism, growth and differentiation, inflammation, cellular survival, as well as in senescence, lifespan extension and several age-related diseases. Sirtuins are NAD+-dependent histone/protein deacetylases (HDAC) and SIRT3 is the only sirtuin whose increased expression has been shown to correlate with an extended life span in humans. It is localized in the mitochondrial matrix, where it regulates the acetylation levels of metabolic enzymes, including acetyl coenzyme A synthetase 2. SIRT3 is stress-responsive and its increased expression protects myocytes from genotoxic and oxidative stress-mediated cell death.Synonyms: NAD-dependent deacetylase sirtuin-3 mitochondrial, SIR2-like protein 3, SIR2L3, SIRT-3, hSIRT3, sirtuin (silent mating type information regulation 2 homolog) 3 (S. cerevisiae), sirtuin 3, sirtuin type 3, sirtuin-3

Gene ID: 23410

NCBI Accession: NP_001017524

UniProt: Q9NTG7