CD41, CD61 antibody

Catalog No. ABIN784612

This Mouse Monoclonal antibody specifically detects CD41, CD61 in FACS, IP, EIA, IHC (fro) and Func. It exhibits reactivity toward Human.

Quick Overview for CD41, CD61 antibody (ABIN784612)

Target: CD41, CD61 (CD41,CD61)

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This CD41, CD61 antibody is un-conjugated

Application: Flow Cytometry (FACS), Immunoprecipitation (IP), Enzyme Immunoassay (EIA), Immunohistochemistry (Frozen Sections) (IHC (fro)), Functional Studies (Func)

Clone: P2

Product Details anti-CD41, CD61 Antibody

Immunogen: Human platelets

Isotype: IgG1

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Reconstitution: Restore with 1 mL distilled water.

Concentration: 0.2 mg/mL (prior to lyophilization)

Buffer: PBS buffer with 1 mg/mL BSA as stabilizer without preservatives

Preservative: Without preservative

Storage: 4 °C

Storage Comment: Store at 2 - 8 °C.

Target Details for CD41, CD61

Target: CD41, CD61 (CD41,CD61)

Background: Integrin alpha 2b (CD41) is a calcium-dependent, noncovalently associated heterodimer and contains a heavy chain (GPIIb alpha) and a light chain (GPIIb beta) linked by a single disulfide bond. The Integrin alpha 2B chain interacts with the Integrin beta 3 subunit/CD61 to form the platelet glycoprotein complex, gpIIb/IIIa. It is expressed on platelets and megakaryocytes. Ligands for the gpIIb/IIIa heterodimer include fibrinogen, von Willebrand factor, fibronectin, vitronectin, and thrombospondin. The gpIIb/IIIa complex is the major Integrin on platelets and is important for platelet adhesion and aggregation.Synonyms: CD41, CD61, GP2B, GP3A, GPIIb, GPIIb-IIIa, GPalpha IIb, ITGA2B, ITGAB, ITGB3, Integrin alpha-IIb, Integrin beta-3, Platelet membrane glycoprotein IIb