BMI1 antibody (Internal Region)

Catalog No. ABIN789019

This Rabbit Polyclonal antibody specifically detects BMI1 in WB, IF and ICC. It exhibits reactivity toward Human, Mouse, Rat, Rabbit, Dog, Cow, Chicken, Zebrafish (Danio rerio) and Protozoa.

Quick Overview for BMI1 antibody (Internal Region) (ABIN789019)

Target: BMI1 (BMI1 Polycomb Ring Finger Oncogene (BMI1))

Reactivity: Human, Mouse, Rat, Rabbit, Dog, Cow, Chicken, Zebrafish (Danio rerio), Protozoa

Host: Rabbit

Clonality: Polyclonal

Conjugate: This BMI1 antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF), Immunocytochemistry (ICC)

Product Details anti-BMI1 Antibody

Binding Specificity: AA 1-100, Internal Region

Cross-Reactivity: Cow (Bovine), Dog (Canine), Chicken, Cat (Feline), Human, Mouse (Murine), Primate, Rabbit, Rat (Rattus)

Purification: affinity purified

Immunogen: A synthetic peptide made to an internal region (within AA 1-100) of the human Bmi1 protein. [Swiss-Prot# P35226].

Isotype: IgG

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Storage: -20 °C

Target Details for BMI1

Target: BMI1 (BMI1 Polycomb Ring Finger Oncogene (BMI1))

Alternative Name: Bmi1

Background: Bmi1 induces telomerase activity and immortalizes human mammary epithelial cells. Bmi1 extends the replicative life span of human fibroblasts by suppressing the p16-dependent senescence pathway. It has also been termed an oncogene with aberrant expression in various carcinomas. It has been shown to be a negative regulator of p19Arf, Ink4a (p14Arf) and tp53 known tumor repressors. Ablation of Bmi1 is required for short term survival of cancer cells. In addition, Bmi1 expression promotes HSC self-renewal. These findings highlight the importance of epigenetic regulation in HSC self-renewal and identify PcG genes as potential targets for therapeutic HSC manipulation.

UniProt: P35226

Pathways: Cell Division Cycle, Autophagy