GRIN2B antibody (pTyr1252)
Quick Overview for GRIN2B antibody (pTyr1252) (ABIN801213)
Target
See all GRIN2B AntibodiesReactivity
Host
Clonality
Conjugate
Application
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Binding Specificity
- pTyr1252
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Specificity
- This antibody may cross react with NMDAR2A (Tyr 1246) due to 75 % sequence similarity.
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Predicted Reactivity
- Human,Mouse,Dog,Cow,Chicken,Rabbit,Guinea Pig
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Purification
- Purified by Protein A.
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Immunogen
- KLH conjugated synthetic phosphopeptide derived from human NMDAR2B around the phosphorylation site of Tyr1252
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Isotype
- IgG
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anti-Glutamate Receptor, Ionotropic, N-Methyl D-Aspartate 2B (GRIN2B) (AA 27-163) antibody
GRIN2B Reactivity: Human ELISA, ICC, FACS Host: Mouse Monoclonal 6E9A8 unconjugated
anti-Glutamate Receptor, Ionotropic, N-Methyl D-Aspartate 2B (GRIN2B) (AA 20-271) antibody (HRP)GRIN2B Reactivity: Rat WB, IHC, IF, IP, ICC, AA Host: Mouse Monoclonal S59 HRP
anti-Glutamate Receptor, Ionotropic, N-Methyl D-Aspartate 2B (GRIN2B) (AA 20-271) antibody (FITC)GRIN2B Reactivity: Rat WB, IHC, IF, IP, ICC, AA Host: Mouse Monoclonal S59 FITC
anti-Glutamate Receptor, Ionotropic, N-Methyl D-Aspartate 2B (GRIN2B) (AA 20-271) antibody (Biotin)GRIN2B Reactivity: Rat WB, IHC, IF, IP, ICC, AA Host: Mouse Monoclonal S59 Biotin
anti-Glutamate Receptor, Ionotropic, N-Methyl D-Aspartate 2B (GRIN2B) (AA 20-271) antibody (PE)GRIN2B Reactivity: Rat WB, IHC, IF, IP, ICC, AA Host: Mouse Monoclonal S59 PE
anti-Glutamate Receptor, Ionotropic, N-Methyl D-Aspartate 2B (GRIN2B) (AA 20-271) antibody (APC)GRIN2B Reactivity: Rat WB, IHC, IF, IP, ICC, AA Host: Mouse Monoclonal S59 APC
anti-Glutamate Receptor, Ionotropic, N-Methyl D-Aspartate 2B (GRIN2B) (AA 20-271) antibody (PerCP)GRIN2B Reactivity: Rat WB, IHC, IF, IP, ICC, AA Host: Mouse Monoclonal S59 PerCP
anti-Glutamate Receptor, Ionotropic, N-Methyl D-Aspartate 2B (GRIN2B) (AA 20-271) antibody (Atto 488)GRIN2B Reactivity: Rat WB, IHC, IF, IP, ICC, AA Host: Mouse Monoclonal S59 Atto 488
anti-Glutamate Receptor, Ionotropic, N-Methyl D-Aspartate 2B (GRIN2B) (AA 20-271) antibody (Atto 594)GRIN2B Reactivity: Rat WB, IHC, IF, IP, ICC, AA Host: Mouse Monoclonal S59 Atto 594
anti-Glutamate Receptor, Ionotropic, N-Methyl D-Aspartate 2B (GRIN2B) (AA 20-271) antibody (Atto 390)GRIN2B Reactivity: Rat WB, IHC, IF, IP, ICC, AA Host: Mouse Monoclonal S59 Atto 390
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Application Notes
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WB 1:300-5000
ELISA 1:500-1000 -
Restrictions
- For Research Use only
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Format
- Liquid
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Concentration
- 1 μg/μL
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Buffer
- 0.01M TBS( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
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Preservative
- ProClin
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Precaution of Use
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
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Storage
- -20 °C
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Storage Comment
- Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
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Expiry Date
- 12 months
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- GRIN2B (Glutamate Receptor, Ionotropic, N-Methyl D-Aspartate 2B (GRIN2B))
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Alternative Name
- NMDAR2B
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Background
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NMDA receptor subtype of glutamate-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine. In concert with DAPK1 at extrasynaptic sites, acts as a central mediator for stroke damage. Its phosphorylation at Ser-1303 by DAPK1 enhances synaptic NMDA receptor channel activity inducing injurious Ca2+ influx through them, resulting in an irreversible neuronal death (By similarity).
Subcellular location: Cell membrane
Synonyms: MRD6, NR2B, hNR3, GluN2B, NMDAR2B, Glutamate receptor ionotropic, NMDA 2B, Glutamate [NMDA] receptor subunit epsilon-2, N-methyl D-aspartate receptor subtype 2B, N-methyl-D-aspartate receptor subunit 3, NR3, GRIN2B
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Gene ID
- 2904
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UniProt
- Q13224
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Pathways
- Response to Growth Hormone Stimulus, Synaptic Membrane, Feeding Behaviour, Regulation of long-term Neuronal Synaptic Plasticity
Target
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