MAP2K4 antibody

Catalog No. ABIN865462

This Mouse Monoclonal antibody specifically detects MAP2K4 in WB, IHC, ELISA and FACS. It exhibits reactivity toward Human.

Quick Overview for MAP2K4 antibody (ABIN865462)

Target: MAP2K4 (Mitogen-Activated Protein Kinase Kinase 4 (MAP2K4))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This MAP2K4 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Flow Cytometry (FACS)

Clone: 5H4

Product Details anti-MAP2K4 Antibody

Purification: Ascitic fluid

Immunogen: Purified recombinant fragment of human MAP2K4 expressed in E. Coli.

Isotype: IgG1

Application Details

Application Notes: WB: 1/500 - 1/2000, IHC: 1/200-1/1000, FC: 1/200-1/400, ELISA: Propose dilution 1/10000.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 100g/100l

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Target Details for MAP2K4

Target: MAP2K4 (Mitogen-Activated Protein Kinase Kinase 4 (MAP2K4))

Alternative Name: MAP2K4

Background: This gene encodes a dual specificity protein kinase that belongs to the Ser/Thr protein kinase family. This kinase is a direct activator of MAP kinases in response to various environmental stresses or mitogenic stimuli. It has been shown to activate MAPK8/JNK1, MAPK9/JNK2, and MAPK14/p38, but not MAPK1/ERK2 or MAPK3/ERK3. This kinase is phosphorylated, and thus activated by MAP3K1/MEKK. The knockout studies in mice suggested the roles of this kinase in mediating survival signal in T cell development, as well as in the organogenesis of liver. Tissue specificity: Abundant expression is seen in the skeletal muscle. It is also widely expressed in other tissues . Synonyms: JNKK, MEK4, MKK4, SEK1, JNKK1, SERK1, MAPKK4, PRKMK4, MAP2K4

Molecular Weight: 42kDa

Gene ID: 6416

Pathways: MAPK Signaling, TLR Signaling, Fc-epsilon Receptor Signaling Pathway, Activation of Innate immune Response, Toll-Like Receptors Cascades, BCR Signaling