MME antibody (AA 6-10)

Catalog No. ABIN871686

The Rabbit Polyclonal anti-MME antibody (ABIN871686) specifically detects MME in WB. The antibody is reactive with Human, Rat and Mouse samples.

Quick Overview for MME antibody (AA 6-10) (ABIN871686)

Target: MME (Membrane Metallo-Endopeptidase (MME))

Reactivity: Human, Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MME antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-MME Antibody

Binding Specificity: AA 6-10

Specificity: The antibody detects endogenous level of total CD10 protein.

Purification: Affinity purified

Immunogen: Peptide sequence around AA 6-10 (S-Q-M-D-I) derived from Human CD10. Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates.

Application Details

Application Notes: Western blotting: 1:500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C/-20 °C

Storage Comment: Store at -20 °C for long term preservation (recommended). Store at 4 °C for short term use.

Target Details for MME

Target: MME (Membrane Metallo-Endopeptidase (MME))

Alternative Name: CD10

Target Type: Chemical

Background: Thermolysin-like specificity, but is almost confined on acting on polypeptides of up to 30 amino acids. Biologically important in the destruction of opioid peptides such as Met- and Leu-enkephalins by cleavage of a Gly-Phe bond. Able to cleave angiotensin-1, angiotensin-2 and angiotensin 1-9. Involved in the degradation of atrial natriuretic factor (ANF). Displays UV-inducible elastase activity toward skin preelastic and elastic fibers.

Molecular Weight: 100 kDa

Gene ID: 4311

NCBI Accession: NP_000893

UniProt: P08473

Pathways: RTK Signaling, Peptide Hormone Metabolism, Regulation of Systemic Arterial Blood Pressure by Hormones, Smooth Muscle Cell Migration