MST1R antibody (pTyr1353)

Catalog No. ABIN872300

The Rabbit Polyclonal anti-MST1R antibody is suitable to detect MST1R in samples from Human. It has been validated for WB, FACS, IHC (p), IF (cc), IF (p) and IHC (fro).

Quick Overview for MST1R antibody (pTyr1353) (ABIN872300)

Target: MST1R (Macrophage Stimulating 1 Receptor (C-Met-Related tyrosine Kinase) (MST1R))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MST1R antibody is un-conjugated

Application: Western Blotting (WB), Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Product Details anti-MST1R Antibody

Binding Specificity: pTyr1353

Purpose: phospho-MST1R (Tyr1353) Polyclonal Antibody

Cross-Reactivity: Human

Predicted Reactivity: Mouse,Rat,Dog,Pig,Horse

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic phosphopeptide derived from human MST1R around the phosphorylation site of Tyr1353

Isotype: IgG

Application Details

Application Notes: WB(1:300-5000),

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

Target Details for MST1R

Target: MST1R (Macrophage Stimulating 1 Receptor (C-Met-Related tyrosine Kinase) (MST1R))

Alternative Name: MST1R

Background:

Synonyms: p-MST1RTyr1353, RON phospho Y1353, MST1Rphospho S1349, c met related tyrosine kinase, CD136 antigen, CDw136, Macrophage stimulating 1 receptor, Macrophage stimulating protein receptor alpha chain, MACROPHAGE STIMULATING PROTEIN RECEPTOR, Macrophage stimulating protein receptor beta chain, MSP receptor, MST1R, p185 RON, PTK 8, ptk8, PTK8 protein tyrosine kinase 8, RON, RON protein tyrosine kinase, Stem cell derived tyrosine kinase.

Background: MST1R/Ron, a HGF Receptor/MET-type protein kinase, mediates the biological activities of macrophage-stimulating protein (MSP), a multifunctional cytokine that regulates cell adhesion, motility, growth, and survival. The protein is a membrane-spanning, disulfide-linked heterodimer, which results from cleavage of a glycosylated precursor into 35-kD (alpha) and 150-kD (beta) subunits. Ligand binding results in tyrosine phosphorylation of the beta chain. In knockout studies, MST1R/RON (-/-) mice failed to survive past the periimplantation period. The MST1R/RON gene has been mapped to 3p21, a region of frequent deletion or mutation in small cell lung and renal carcinoma, and has been implicated in the progression of several epithelial cancers. Ron expression has been documented in many normal human tissues. ESTs have been isolated from several tissue libraries, including normal colon, mouth, prostate, and testis and cancerous colon, prostate, stomach, and uterus.

Gene ID: 4486

Pathways: RTK Signaling