NLRP1 antibody (AA 301-400) (Cy3)

Catalog No. ABIN886477

This Rabbit Polyclonal antibody specifically detects NLRP1 in WB, IF (cc) and IF (p). It exhibits reactivity toward Human and Mouse.

Quick Overview for NLRP1 antibody (AA 301-400) (Cy3) (ABIN886477)

Target: NLRP1 (NLR Family, Pyrin Domain Containing 1 (NLRP1))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This NLRP1 antibody is conjugated to Cy3

Application: Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Product Details anti-NLRP1 Antibody (Cy3)

Binding Specificity: AA 301-400

Cross-Reactivity: Human, Mouse

Predicted Reactivity: Rat

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human CARD7/NALP1

Isotype: IgG

Application Details

Application Notes: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for NLRP1

Target: NLRP1 (NLR Family, Pyrin Domain Containing 1 (NLRP1))

Alternative Name: CARD7

Background:

Synonyms: LRR and PYD domains-containing protein 1, CARD 7, CARD7, Caspase recruitment domain protein 7, Caspase recruitment domain-containing protein 7, CLR17.1, Death effector filament forming Ced 4 like apoptosis protein, Death effector filament-forming ced-4-like apoptosis protein, DEFCAP, DEFCAP L/S, NAC alpha/beta/gamma/delta, NAC, NACHT, NACHT leucine rich repeat and PYD containing 1, NACHT leucine rich repeat and PYD pyrin domain containing 1, NACHT leucine rich repeat and pyrin domain containing 1, NACHT LRR and PYD containing protein 1, NALP 1, NALP1, NALP1_HUMAN, NLR family pyrin domain containing 1, NLRP 1, NLRP1, NLRP1 protein, Nucleotide binding domain and caspase recruitment domain, Nucleotide binding oligomerization domain leucine rich repeat and pyrin domain containing 1, Nucleotide-binding domain and caspase recruitment domain, PP 1044, PP1044.

Background: This gene encodes a member of the Ced-4 family of apoptosis proteins. Ced-family members contain a caspase recruitment domain (CARD) and are known to be key mediators of programmed cell death. The encoded protein contains a distinct N-terminal pyrin-like motif, which is possibly involved in protein-protein interactions. This protein interacts strongly with caspase 2 and weakly with caspase 9. Overexpression of this gene was demonstrated to induce apoptosis in cells. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene, but the biological validity of some variants has not been determined. [provided by RefSeq, Jul 2008].

Gene ID: 22861

Pathways: Positive Regulation of Endopeptidase Activity, Inflammasome