Endothelin 1 antibody (AA 53-73) (AbBy Fluor® 647)

Catalog No. ABIN895748

The Rabbit Polyclonal anti-Endothelin 1 antibody has been validated for WB, IF (p) and IF (cc). It is suitable to detect Endothelin 1 in samples from Human, Rat, Pig and Mouse.

Quick Overview for Endothelin 1 antibody (AA 53-73) (AbBy Fluor® 647) (ABIN895748)

Target: Endothelin 1 (EDN1)

Reactivity: Human, Rat, Pig, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Endothelin 1 antibody is conjugated to AbBy Fluor® 647

Application: Western Blotting (WB), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunofluorescence (Cultured Cells) (IF (cc))

Product Details anti-Endothelin 1 Antibody (AbBy Fluor® 647)

Binding Specificity: AA 53-73

Cross-Reactivity: Human, Mouse, Pig, Rat

Predicted Reactivity: Dog,Cow,Sheep,Horse,Guinea Pig

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human human Endothelin-1

Isotype: IgG

Application Details

Application Notes: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for Endothelin 1

Target: Endothelin 1 (EDN1)

Alternative Name: Endothelin-1

Background:

Synonyms: Endothelin-1, EDN 1, EDN1, EDN1 protein, Endothelin1, ET 1,ET1,

Background: Endothelins (ET) show potent constrictor activity in vascular and non-vascular smooth muscle. This family of 21-amino acid peptides exists in at least three isoforms - ET-1, ET-2, and ET-3, and is produced in endothelial and epithelial cells. ET's can mediate biological effects in cells and tissues, and have been shown to bind to an ET receptor in the lung, kidney, heart, and liver. Endothelin 1 is expressed in lung, placental stem villi vessels and in cultured placental vascular smooth muscle cells.

Gene ID: 1906

Pathways: Hormone Transport, Negative Regulation of Hormone Secretion, Regulation of Systemic Arterial Blood Pressure by Hormones, cAMP Metabolic Process, Regulation of Muscle Cell Differentiation, Regulation of G-Protein Coupled Receptor Protein Signaling, Regulation of Cell Size