HMGCR antibody (AA 251-350) (AbBy Fluor® 647)

Catalog No. ABIN901017

The AbBy Fluor® 647-conjugated Rabbit Polyclonal anti-HMGCR antibody (ABIN901017) specifically detects HMGCR in WB. The antibody is reactive with Human samples.

Quick Overview for HMGCR antibody (AA 251-350) (AbBy Fluor® 647) (ABIN901017)

Target: HMGCR (3-Hydroxy-3-Methylglutaryl-CoA Reductase (HMGCR))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This HMGCR antibody is conjugated to AbBy Fluor® 647

Application: Western Blotting (WB)

Product Details anti-HMGCR Antibody (AbBy Fluor® 647)

Binding Specificity: AA 251-350

Purpose: HMGCR Polyclonal Antibody, AbBy Fluor-647 Conjugated

Cross-Reactivity: Human

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human HMGCR

Isotype: IgG

Application Details

Application Notes: WB(1:1000-5000)

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for HMGCR

Target: HMGCR (3-Hydroxy-3-Methylglutaryl-CoA Reductase (HMGCR))

Alternative Name: HMGCR

Background:

Synonyms: LDLCQ3, 3-hydroxy-3-methylglutaryl-coenzyme A reductase, HMG-CoA reductase, HMGCR

Background: Transmembrane glycoprotein that is the rate-limiting enzyme in cholesterol biosynthesis as well as in the biosynthesis of nonsterol isoprenoids that are essential for normal cell function including ubiquinone and geranylgeranyl proteins.

Gene ID: 3156

UniProt: P04035

Pathways: AMPK Signaling, Negative Regulation of Hormone Secretion, Regulation of Lipid Metabolism by PPARalpha