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NLRP4 antibody (AA 351-450) (Cy7)

NLRP4 Reactivity: Human, Rat IF (cc), IF (p) Host: Rabbit Polyclonal Cy7
Catalog No. ABIN907635
  • Target See all NLRP4 Antibodies
    NLRP4 (NLR Family, Pyrin Domain Containing 4 (NLRP4))
    Binding Specificity
    • 14
    • 8
    • 7
    • 6
    • 1
    • 1
    AA 351-450
    Reactivity
    • 32
    • 14
    • 2
    Human, Rat
    Host
    • 32
    Rabbit
    Clonality
    • 32
    Polyclonal
    Conjugate
    • 9
    • 3
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This NLRP4 antibody is conjugated to Cy7
    Application
    • 18
    • 16
    • 12
    • 12
    • 4
    • 4
    • 1
    • 1
    • 1
    Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
    Specificity
    This antibody will detect multiple forms of NALP4, including the A, C and E Mouse variants.
    Cross-Reactivity
    Human, Rat
    Predicted Reactivity
    Mouse,Pig,Horse
    Purification
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic peptide derived from human NALP4
    Isotype
    IgG
    Top Product
    Discover our top product NLRP4 Primary Antibody
  • Application Notes
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 μg/μL
    Buffer
    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
    Preservative
    ProClin
    Precaution of Use
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
    Expiry Date
    12 months
  • Target
    NLRP4 (NLR Family, Pyrin Domain Containing 4 (NLRP4))
    Alternative Name
    NALP4 (NLRP4 Products)
    Synonyms
    CLR19.5 antibody, CT58 antibody, NALP4 antibody, PAN2 antibody, PYPAF4 antibody, RNH2 antibody, Nalp4 antibody, Nlrp4e antibody, RGD1563529 antibody, NLR family pyrin domain containing 4 antibody, NLR family, pyrin domain containing 4 antibody, NLRP4 antibody, Nlrp4 antibody
    Background

    Synonyms: NACHT, LRR and PYD domains-containing protein 4, Cancer/testis antigen 58, CT58, PAAD and NACHT-containing protein 2, PAN2, PYRIN and NACHT-containing protein 2, PYRIN-containing APAF1-like protein 4, PYPAF4, Ribonuclease inhibitor 2, NLRP4, NALP4, RNH2

    Background: May be involved in inflammation and recognition of cytosolic pathogen-associated molecular patterns (PAMPs) not intercepted by membrane-bound receptors. Acts as a negative regulator of the type I interferon signaling pathway by serving as an adapter to promote DTX4-mediated ubiquitination of activated TBK1, and its subsequent degradation. Suppresses NF-kappaB induction by the cytokines TNFA and IL1B, suggesting that it operates at a point of convergence in these two cytokine signaling pathways.

    Gene ID
    147945
    UniProt
    Q96MN2
    Pathways
    Inflammasome
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