NLRP4 antibody (AA 351-450) (HRP)

Catalog No. ABIN907644

Product Details anti-NLRP4 Antibody

Target: NLRP4 (NLR Family, Pyrin Domain Containing 4 (NLRP4))

Binding Specificity: AA 351-450

Reactivity: Human, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This NLRP4 antibody is conjugated to HRP

Application: Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Specificity: This antibody will detect multiple forms of NALP4, including the A, C and E Mouse variants.

Predicted Reactivity: Mouse,Pig,Horse

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human NALP4

Isotype: IgG

Application Details

Application Notes: IHC-P 1:200-400
IHC-F 1:100-500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Handling Advice: Do NOT add Sodium Azide! Use of Sodium Azide will inhibit enzyme activity of horseradish peroxidase.

Storage: -20 °C/-80 °C

Storage Comment: Store at -20°C, for long storage, store at -80°C. Avoid multiple freeze-thaw cycles

Expiry Date: 12 months

Target Details for NLRP4

Target: NLRP4 (NLR Family, Pyrin Domain Containing 4 (NLRP4))

Alternative Name: NALP4 (NLRP4 Products)

Synonyms: CLR19.5 antibody, CT58 antibody, NALP4 antibody, PAN2 antibody, PYPAF4 antibody, RNH2 antibody, Nalp4 antibody, Nlrp4e antibody, RGD1563529 antibody, NLR family pyrin domain containing 4 antibody, NLR family, pyrin domain containing 4 antibody, NLRP4 antibody, Nlrp4 antibody

Background:

May be involved in inflammation and recognition of cytosolic pathogen-associated molecular patterns (PAMPs) not intercepted by membrane-bound receptors. Acts as a negative regulator of the type I interferon signaling pathway by serving as an adapter to promote DTX4-mediated ubiquitination of activated TBK1, and its subsequent degradation. Suppresses NF-kappaB induction by the cytokines TNFA and IL1B, suggesting that it operates at a point of convergence in these two cytokine signaling pathways.

Subcellular location: Cytoplasm, Secreted, Extracellular matrix

Synonyms: NACHT, LRR and PYD domains-containing protein 4, Cancer/testis antigen 58, CT58, PAAD and NACHT-containing protein 2, PAN2, PYRIN and NACHT-containing protein 2, PYRIN-containing APAF1-like protein 4, PYPAF4, Ribonuclease inhibitor 2, NLRP4, NALP4, RNH2

Gene ID: 147945

UniProt: Q96MN2

Pathways: Inflammasome